Endothelin receptor type A and B gene expression in human nonpregnant, term pregnant, and preeclamptic uterus

American Journal of Obstetrics and Gynecology
K WolffB Lindblom

Abstract

The aim of this study was to quantify the gene expression of ETA and ETB receptors within the different uterine segments of nonpregnant, normal pregnant, and preeclamptic women. Biopsy samples from the cervix, isthmus, and corpus uteri were obtained from eight nonpregnant, nine term pregnant, and seven preeclamptic women. The concentration of ETA and ETB receptor messenger ribonucleic acid were determined by a solution hybridization technique with complementary ribonucleic acid probes. Results are presented in counts per minute per microgram of total nucleic acid as mean +/- SEM. The expression of messenger ribonucleic acid encoding the ETA receptor was generally higher in the upper than in the lower uterine segment in nonpregnant, normal pregnant, and preeclamptic myometrium, whereas the opposite pattern was seen with regard to ETB. During normal pregnancy the concentrations of ETA receptor messenger ribonucleic acid in the corpus and ETB receptor messenger ribonucleic acid in the isthmus were significantly elevated compared with those in nonpregnant women. This enhanced gene expression was, however, not observed in the preeclamptic group. Our finding of segmentally differentiated endothelin receptor gene expression is compati...Continue Reading

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Citations

Apr 11, 2018·Current Hypertension Reports·Joey P GrangerBhavisha A Bakrania
Apr 6, 2019·Current Pharmaceutical Design·Emilie HitzerdA H Jan Danser
Feb 21, 2002·Critical Care Nursing Quarterly·A D Angerio
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·P HatthachoteJ I Gillespie
Apr 18, 2013·Molecular Endocrinology·Yanping ZhangL Bruno Ruest
Jun 22, 2019·Clinical Science·Emilie HitzerdLangeza Saleh
Aug 10, 2021·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja

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