PMID: 8945919Nov 1, 1996Paper

Endothelin receptors are modulated in association with endogenous fluctuations in estrogen

The American Journal of Physiology
D A BarberV M Miller

Abstract

Experiments were designed to determine whether endogenous physiological fluctuations in sex steroid hormones affect expression or functional responses of endothelin receptors. Coronary arteries from sexually mature male, female, and ovariectomized pigs were prepared either for receptor binding or measurement of isometric force in organ chambers. Competitive binding of 125I-labeled endothelin-1 was significant for a one-site model with unlabeled endothelin-1 and a two-site model with unlabeled endothelin-3 and sarafotoxin S6c in all pigs. The total number of binding sites for all endothelin ligands was not different between male and female pigs. Binding affinities for the high-affinity binding site for both endothelin-3 and sarafotoxin S6c were significantly greater (lower inhibition constant) in membranes prepared from female pigs with high endogenous estrogen. In organ chamber experiments, contractions to endothelin-1 but not endothelin-3 or sarafotoxin S6c were significantly greater in coronary arterial rings from female compared with male pigs and were not affected significantly by removal of the endothelium or by treatment of the rings with either indomethacin (10(-5) mol/l) or the combination of indomethacin and NG-monomet...Continue Reading

Citations

May 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ritu ChatrathVirginia M Miller
Jun 10, 2003·Journal of Applied Physiology·Ritu ChatrathVirginia M Miller
Jun 1, 2004·Journal of Applied Physiology·Muthuvel JayachandranVirginia M Miller

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