PMID: 8587405Jan 1, 1995Paper

Endothelin receptors in ischemic rat brain and Alzheimer brain

Journal of Cardiovascular Pharmacology
M KohzukiK Abe

Abstract

Endothelin (ET) binding sites in male Wistar rat brains subjected to a 20-min four-vessel occlusion (transient forebrain ischemia model) which induces hippocampal neuron death, and in human brains with Alzheimer disease, were mapped by quantitative in vitro autoradiography employing [125I]ET-1 as a radioligand. Rats were decapitated 4 or 7 days after ischemia. In the rat brain, the [125I]ET-1 binding sites were remarkably increased in the hippocampal CA1 and dentate gyrus, ventral thalamic nucleus, and cortical vessels 4 and 7 days after ischemia, when many reactive astroglia were observed. The [125I]ET-1 binding sites decreased in the cerebral cortex affected by Alzheimer disease. The binding was abolished by 1 microM unlabeled ET-1, ET-3, sarafotoxin S6b, and BQ788 (an ETB antagonist) but not by BQ123 (an ETA antagonist), suggesting that the [125I]ET-1 binding sites are as ETB receptors. The present findings raise the possibility that a glial ET system could be responsible for the occurrence of ischemic neuron cell death.

Citations

Sep 1, 2005·Experimental Eye Research·Vanesa TorbidoniAngela M Suburo
Feb 12, 2000·Progress in Neurobiology·M van den Buuse, K M Webber
Sep 25, 2010·Peptides·Talia Filipovich-Rimon, Sigal Fleisher-Berkovich
Dec 17, 2009·Regulatory Peptides·E M VingoloC Letizia
Oct 8, 2008·Peptides·Talia Filipovich, Sigal Fleisher-Berkovich
Nov 25, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·B Battistini, P Dussault
May 22, 1998·Journal of Cardiovascular Pharmacology·M KohzukiT Sato

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