Endothelin receptors in the cornea, iris and ciliary processes. Evidence from binding, secondary messenger and PCR studies

Experimental Eye Research
N N OsborneW Luttmann

Abstract

Endothelin (ET)-1 (10 nanoM) is about six times more effective than ET-3 in contracting the isolated iris sphincter muscle; the ET-1-induced contraction is insensitive to indomethacin treatment. The effect of ET-2 is intermediatory between ET-1 and ET-3 in contracting the muscle. The relative potency of the ETs to stimulate inositol phosphates (InsPs) in the iris-ciliary processes is ET-1 > ET-2 > ET-3, with ET-1 about six times more potent then ET-3; these effects are also insensitive to indomethacin. Studies utilizing the polymerase chain reaction (PCR) show that ETB receptors are present. Although no evidence could be found for the occurrence of ETA receptors, their presence cannot be excluded. These results suggest that the stimulation of InsPs and contraction of the iris sphincter muscle by ET is mediated by ETB receptors and that products generated via activation of phospholipase A2 are not directly involved in the observed responses. However, another type of ET receptor is indicated by the finding that ET-1 reduced the forskolin-elevated cAMP levels in the iris-ciliary epithelium. Autoradiographic results show that specific [125I]ET-1 binding sites are associated with the iris, ciliary processes and the corneal endotheli...Continue Reading

Citations

Sep 27, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·K Y WuH Z Wang
Mar 22, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Show-Jen HongJim C Fong
Feb 24, 2016·Journal of Ophthalmology·Lars ChoritzHagen Thieme
May 21, 1998·Japanese Journal of Pharmacology·C NosakaY Harada
Jan 1, 1995·Experimental Eye Research·L P Bausher, B Horio
Jul 26, 2002·Journal of Glaucoma·Thomas YorioGanesh Prasanna
Jun 17, 1998·Experimental Eye Research·A RipodasR Fernandez-Durango

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