PMID: 8960383Aug 1, 1996Paper

Endothelin receptors mediating vasoconstriction in rat pressurized small arteries

Canadian Journal of Physiology and Pharmacology
A M Sharifi, E L Schiffrin

Abstract

The effects of endothelin-1 (ET-1), a nonselective ETA and ETB receptor agonist, and sarafotoxin S6c, a selective ETB agonist, were investigated in the presence and absence of BQ123 and BQ788, ETA- and ETB-selective antagonists, respectively, in rat mesenteric small arteries, using a perfusion pressurized arteriograph in which segments of vessels were cannulated and exposed to constant pressure and flow. ET-1 (10(-13)-10(-7) M) induced vasoconstriction in both intact and endothelium-denuded arteries in a concentration-dependent manner. BQ123 (10(-7) and 10(-6) M) inhibited the effect of ET-1, displacing the concentration-response curve to the right in a concentration-dependent manner. The effect of ET-1 was not significantly affected by BQ788 (10(-7) and 10(-6) M), a selective antagonist of ETB receptors. Sarafotoxin S6c (10(-11)-10(-7) M) also induced a slight concentration-dependent vasoconstriction. The effect of sarafotoxin S6c (10(-8) M) was inhibited by the ETB-selective antagonist BQ788 (10(-7) M), but was not significantly changed by BQ123 (10(-7) M). Vasoconstriction induced by sarafotoxin S6c (10(-8) M) in a single bolus concentration was significantly greater than the contraction induced by the same concentration as ...Continue Reading

References

Apr 15, 1992·Biochemical and Biophysical Research Communications·S MorelandJ T Hunt
Jul 1, 1991·Hypertension·T NabikaY Yamori
May 31, 1991·Biochemical and Biophysical Research Communications·J G FilepP Sirois
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A InoueT Masaki
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L SchillingM Wahl
Apr 1, 1993·The Journal of Clinical Investigation·Y HirataF Marumo
Apr 1, 1995·Hypertension·K T StepniakowskiB M Egan
Jan 1, 1995·Hypertension·F J VillarrealW H Dillmann
Apr 1, 1994·Circulation·J T Willerson

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Citations

Aug 28, 1998·British Journal of Pharmacology·C Docherty, M R MacLean
Feb 16, 2008·Critical Reviews in Food Science and Nutrition·Qiaofen Cheng, Da-Wen Sun
Jul 6, 2013·Canadian Journal of Physiology and Pharmacology·Saad EnouriRon Johnson
Dec 11, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hilda AhnstedtLars Edvinsson
Feb 3, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Martina WendelThea Koch
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A CahillJ V Sitzman

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