Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia

Current Neuropharmacology
A Gulati

Abstract

Neurogenesis is most active during pre-natal development, however, it persists throughout the human lifespan. The putative role of mitochondria in neurogenesis and angiogenesis is gaining importance. Since, ETB receptor mediated neurogenesis and angiogenesis has been identified, the role of these receptors with relevance to mitochondrial functions is of interest. In addition to work from our laboratory, we undertook an extensive search of bibliographic databases for peer-reviewed research literature. Specific technical terms such as endothelin, mitochondria and neurogenesis were used to seek out and critically evaluate literature that was relevant. The ET family consists of three isopeptides (ET-1, ET-2 and ET-3) that produce biological actions by acting on two types of receptors (ETA and ETB). In the central nervous system (CNS) ETA receptors are potent constrictors of the cerebral vasculature and appear to contribute in the causation of cerebral ischemia. ETA receptor antagonists have been found to be effective in animal model of cerebral ischemia; however, clinical studies have shown no efficacy. Mitochondrial functions are critically important for several neural development processes such as neurogenesis, axonal and dendrit...Continue Reading

Citations

Mar 3, 2020·Canadian Journal of Physiology and Pharmacology·Yasir AbdulAdviye Ergul
Sep 17, 2020·Canadian Journal of Physiology and Pharmacology·Bambang Widyantoro, Noriaki Emoto
Jun 24, 2020·Canadian Journal of Physiology and Pharmacology·Amaresh K RanjanAnil Gulati
Nov 28, 2018·Cells·Zhengqiu ZhouRamon Sun
Apr 17, 2020·Early Human Development·Peter KorčekZbyněk Straňák

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