PMID: 9648867Jul 2, 1998Paper

Endothelin-stimulated capacitative calcium entry in enteric glial cells: synergistic effects of protein kinase C activity and nitric oxide

Journal of Neurochemistry
W ZhangM W Mulholland

Abstract

Depletion of intracellular calcium stores by agonist stimulation is coupled to calcium influx across the plasma membrane, a process termed capacitative calcium entry. Capacitative calcium entry was examined in cultured guinea pig enteric glial cells exposed to endothelin 3. Endothelin 3 (10 nM) caused mobilization of intracellular calcium stores followed by influx of extracellular calcium. This capacitative calcium influx was inhibited by Ni2+ (89 +/- 2%) and by La3+ (78 +/- 2%) but was not affected by L-, N-, or P-type calcium channel blockers. Chelerythrine, a specific antagonist of protein kinase C, dose-dependently inhibited capacitative calcium entry. The nitric oxide synthase inhibitor NG-nitro-L-arginine decreased calcium influx in a dose-dependent manner. The combination of chelerythrine and NG-nitro-L-arginine produced synergistic inhibitory effects. Capacitative calcium entry occurs in enteric glial cells via lanthanum-inhibitable channels through a process regulated by protein kinase C and nitric oxide.

Citations

Jun 6, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T LinM Mulholland
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A RühlK A Sharkey
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A Rühl
Feb 8, 2019·Glia·Werend BoesmansPieter Vanden Berghe
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·P vanden BergheJ Janssens
Mar 22, 2002·British Journal of Pharmacology·Kuo-Jung LoSheau-Huei Chueh
Jan 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W BoesmansP Vanden Berghe
Oct 30, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terence Keith Smith, Sang Don Koh
May 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·R BisschopsJ Tack
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Jianliang ZhangJawaharlal M Patel
Jan 21, 2004·The Journal of Surgical Research·B J SeguraM W Mulholland

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