Endothelin stimulates protein phosphorylation in blood-brain barrier

Biochemical and Biophysical Research Communications
R E CatalánG Diáz

Abstract

The vasoactive neuropeptide endothelin stimulated phosphorylation of specific proteins in rat brain microvessels. Major effects were observed with endothelin-1. These effects were dose- and time-dependent. Among substrates for kinase actions, the 17.5 KDa and 80 KDa proteins were mainly affected by endothelin-1. It was demonstrated that the 80 KDa protein affected corresponds to MARCKS (myristoylated alanine-rich C kinase substrate), a specific substrate for protein kinase C action.

Citations

Jan 4, 2012·Journal of Pharmaceutical Sciences·Pooja Naik, Luca Cucullo
Oct 7, 2004·Neuropeptides·María del Rosario Garrido, Anita Israel
Jun 6, 2003·Biochemical and Biophysical Research Communications·M Pilar ColladoR Edgardo Catalán
Aug 8, 2014·Pharmaceutical Research·Christopher A PalmiottiLuca Cucullo
Nov 12, 2003·Microvascular Research·M Pilar ColladoR Edgardo Catalán

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