Endothelium and cancer metastasis: Perspectives for antimetastatic therapy

Pharmacological Reports : PR
Agnieszka BlazejczykJoanna Wietrzyk

Abstract

Endothelial cells accompany the malignant cancer cell in almost every stage of metastatic process which includes: infiltration of tumor cells into the neighboring tissue, transmigration through endothelium (intravasation), survival in the blood stream, and extravasation followed by colonization of the target organ. The blood vessels within the tumor are heterogeneous, highly permeable, and chaotically branched therefore often described as abnormal or dysfunctional. These abnormalities are common for all components of the vessel wall and result from the activity of such factors as hypoxia and chronic growth factor stimulation. In this review, we focus not only on the distinctions in terms of the characteristic and function of tumor endothelial cells (TEC) as compared to normal endothelial cells (NEC), but also on all of these metastasis steps, which are accompanied by endothelial mediated mechanisms. Moreover, some therapeutic approaches directly or indirectly targeting the endothelium are discussed.

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·M Schirner, M R Schneider
Jan 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P B VermeulenL Y Dirix
Oct 27, 1999·Nitric Oxide : Biology and Chemistry·M D Jyothi, A Khar
Apr 7, 2000·The American Journal of Pathology·H HashizumeD M McDonald
May 9, 2000·Lancet·J N George
Jun 6, 2000·Biochimica Et Biophysica Acta·C MichielsJ Remacle
Aug 19, 2000·Science·B St CroixK W Kinzler
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChangL L Munn
Feb 24, 2001·Clinical & Experimental Metastasis·G MannoriS Ruggieri
Feb 20, 2002·FEBS Letters·Frode SelheimFlemming S Vassbotn
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benedetta BussolatiGiovanni Camussi
Jul 16, 2003·Cold Spring Harbor Symposia on Quantitative Biology·R Pasqualini, W Arap
Aug 2, 2003·The New England Journal of Medicine·James C YangSteven A Rosenberg
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
Nov 18, 2005·The Urologic Clinics of North America·Robert A Kloner
Nov 22, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Emma L Williams, Mustafa B A Djamgoz
Dec 31, 2005·Cardiovascular Drugs and Therapy·Wolfgang Schaper
Jan 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Carlos MedinaMarek W Radomski
Mar 22, 2006·The Oncologist·Katja HindlerCharles D Collard
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroyasu YasudaMutsuo Yamaya
Mar 17, 2007·Cancer Research·Jeffrey B WyckoffJohn Condeelis
Jun 15, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nina HostettlerLubor Borsig
Jan 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dipak PanigrahyMark W Kieran
Nov 28, 2008·Blood·Giannoula Lakka KlementJudah Folkman
Feb 6, 2009·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·Marcelo FigueiredoLeonardo Soares
Jun 2, 2009·Seminars in Cancer Biology·Vanessa Baeriswyl, Gerhard Christofori
Jul 17, 2009·Cardiovascular Therapeutics·Steen Husted, J J J van Giezen
Jul 30, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu-Quan XiongZhao-You Tang
Mar 23, 2010·Biochemical and Biophysical Research Communications·Kohei MatsudaKyoko Hida
Apr 8, 2010·Cell·Bin-Zhi Qian, Jeffrey W Pollard

❮ Previous
Next ❯

Citations

Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Jul 15, 2016·Journal of Experimental & Clinical Cancer Research : CR·Agnieszka BlazejczykJoanna Wietrzyk
Sep 17, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yu SakuraiHideyoshi Harashima
Oct 19, 2019·Cancers·Beatriz P San JuanChristine L Chaffer
Jun 11, 2016·Oncotarget·Elizabeth A VitelloAlvin Y Liu
Apr 20, 2018·Phytotherapy Research : PTR·Bahare SalehiJavad Sharifi-Rad
Nov 9, 2016·International Journal of Oncology·Ewa MajJoanna Wietrzyk
Mar 9, 2017·BMC Cancer·Agnieszka DenslowJoanna Wietrzyk
Feb 12, 2021·Translational Oncology·Chia Yin GohAmanda McCann
Jun 3, 2021·International Journal of Molecular Sciences·Lisa SchneiderAxel John

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Experimental Medicine and Biology
Joan Chang, Janine Erler
Nature Reviews. Cancer
Nicolas ReymondAnne J Ridley
Journal of the American Academy of Dermatology
D G Brodland, J A Zitelli
© 2021 Meta ULC. All rights reserved