Endothelium as a Potential Target for Treatment of Abdominal Aortic Aneurysm

Oxidative Medicine and Cellular Longevity
Jingyuan SunLing Gao

Abstract

Abdominal aortic aneurysm (AAA) was previously ascribed to weaken defective medial arterial/adventitial layers, for example, smooth muscle/fibroblast cells. Therefore, besides surgical repair, medications targeting the medial layer to strengthen the aortic wall are the most feasible treatment strategy for AAA. However, so far, it is unclear whether such drugs have any beneficial effect on AAA prognosis, rate of aneurysm growth, rupture, or survival. Notably, clinical studies have shown that AAA is highly associated with endothelial dysfunction in the aged population. Additionally, animal models of endothelial dysfunction and endothelial nitric oxide synthase (eNOS) uncoupling had a very high rate of AAA formation, indicating there is crucial involvement of the endothelium and a possible pharmacological solution targeting the endothelium in AAA treatment. Endothelial cells have been found to trigger vascular wall remodeling by releasing proteases, or recruiting macrophages along with other neutrophils, into the medial layer. Moreover, inflammation and oxidative stress of the arterial wall were induced by endothelial dysfunction. Interestingly, there is a paradoxical differential correlation between diabetes and aneurysm formatio...Continue Reading

References

Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Oct 31, 2000·Circulation Research·Z G JinB C Berk
Mar 27, 2002·Circulation·Dan SorescuKathy K Griendling
May 21, 2003·Journal of Vascular Surgery·David C BrewsterUNKNOWN Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery
Jan 14, 2004·Journal of Vascular Surgery·K Craig KentUNKNOWN Society for Vascular Medicine and Biology
Mar 11, 2004·Experimental and Molecular Pathology·Eiketsu ShoRonald L Dalman
May 4, 2005·Lancet·N SakalihasanO D Defawe
Jul 7, 2005·Circulation·Kevin K HannawaGilbert R Upchurch
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Manu O PlattHanjoong Jo
Dec 22, 2006·Annals of the New York Academy of Sciences·Kevin K HannawaGilbert R Upchurch
Jul 7, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S S M RensenG J J M van Eys
Dec 26, 2007·Archives of Physiology and Biochemistry·A ManeaM Raicu
Apr 5, 2008·European Journal of Cell Biology·Sabine ErdmannKatharina Spanel-Borowski
May 27, 2008·Atherosclerosis·Wanfen XiongJason Johanning
May 21, 2009·Cardiovascular Research·Takashi Miyake, Ryuichi Morishita
May 27, 2009·Nature Reviews. Cardiology·Femke A M V I HellenthalGeert Willem H Schurink
Nov 4, 2009·Nature Reviews. Cardiology·Ismail El-Hamamsy, Magdi H Yacoub
Dec 2, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S ShantikumarD J A Scott
Jul 20, 2010·Amino Acids·T Klein, R Bischoff
Aug 4, 2010·Journal of Vascular Surgery·Noriyuki MiyamaRonald L Dalman
Sep 3, 2010·Current Vascular Pharmacology·Veeru KasivisvanathanAlun H Davies
Sep 3, 2010·Cardiovascular Drugs and Therapy·Jonathan GolledgeCatherine Rush
Nov 17, 2010·Nature Reviews. Cardiology·Ian M NordonMatt M Thompson
Jan 6, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jesper SwedenborgPetri T Kovanen
Jan 11, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F L MollUNKNOWN European Society for Vascular Surgery
Apr 16, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Irene HinterseherHelena Kuivaniemi
Sep 20, 2011·The British Journal of Surgery·A M ConwayI M Loftus
Mar 6, 2012·The British Journal of Surgery·M J SweetingUNKNOWN RESCAN collaborators
Jun 15, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A Piechota-PolanczykM Klinger

❮ Previous
Next ❯

Citations

Feb 15, 2019·Circulation Research·Raymundo Alain Quintana, W Robert Taylor
Aug 30, 2018·Molecular and Cellular Biochemistry·Danielle Jacques, Ghassan Bkaily
Feb 12, 2021·International Journal of Molecular Sciences·Alison DominguesValérie Nivet-Antoine
May 1, 2021·Journal of Clinical Medicine·Petroula NanaGeorge Kouvelos
Oct 27, 2021·European Journal of Clinical Investigation·Karlijn B RomboutsKak Khee Yeung

❮ Previous
Next ❯

Methods Mentioned

BETA
exome sequencing

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.