Endothelium-Dependent and -Independent Vasodilator Effects of Dimethyl Sulfoxide in Rat Aorta

Pharmacology
Takeharu KanedaKazumasa Shimizu

Abstract

This study examined the mechanism of vasorelaxation induced by dimethyl sulfoxide (DMSO) in endothelium-intact and -denuded rat aorta. DMSO (0.1-3%) inhibited phenylephrine (PE, 1 μmol/l)-induced contraction in a dose-dependent manner. However, this relaxation was lower in the absence of the endothelium. Increase in DMSO-induced relaxation in the presence of the endothelium was attenuated by preincubation in L-NG-nitroarginine methyl ester (L-NAME, 100 μmol/l) and by the removal of the endothelium. In the aorta with endothelium, DMSO (3%) and CCh (3 μmol/l) increased cGMP contents, significantly and L-NAME (100 μmol/l) inhibited the DMSO-induced increases of cGMP. In fura 2-loaded endothelium-denuded aorta, cumulative application of DMSO (1-3%) inhibited PE-induced muscle tension; however, this application did not affect the [Ca2+]i level. In PE-precontracted endothelium-denuded aorta, relaxation responses to fasudil were significantly less in the presence of DMSO compared to the control. These results suggest that DMSO causes relaxation by increasing the cGMP content in correlation with the release of NO from endothelial cells and by decreasing the Ca2+ sensitivity of contractile elements partly via inhibiting Rho-kinase in ra...Continue Reading

Citations

May 12, 2018·European Journal of Nutrition·Kirsty MacRaeAndrew Fenning
Jul 4, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Yann SavinaJeremy Bellien
Sep 2, 2017·Journal of Applied Physiology·Caroline J SmithLacy M Alexander
Nov 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Dylan OlverJaume Padilla
Jan 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tamkeen Urooj ParachaKrongkarn Chootip
Aug 16, 2019·Toxicology and Applied Pharmacology·Evellyn Rodrigues CordeiroDalton Valentim Vassallo
Jan 15, 2021·Bioorganic & Medicinal Chemistry Letters·Chang-Bo ZhengXun Li
Aug 20, 2021·Canadian Journal of Physiology and Pharmacology·Oğuzhan Ekin EfeSelda Emre Aydingoz

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