Endothelium-dependent and independent enhancement of vascular contractility in the ovariectomized rabbit

Journal of the Society for Gynecologic Investigation
Miho KogaHideo Kanaide

Abstract

Estrogen suppresses contractile response and increases vasodilator response, partly by modulating endothelial function. However, the effect of estrogen on the contractility of vascular smooth muscle remains to be elucidated. We investigated the effect of a long-term estrogen deficiency on vascular contractility and the Ca(2+) sensitivity of the contractile apparatus in arterial smooth muscle. Female rabbits were divided into the following three groups: control group, an ovariectomized group (OVX), and a group supplemented with 17beta-estradiol after ovariectomy (OVX+E2). Twelve weeks later, the mesenteric artery was isolated, and the vascular contractility was evaluated. In OVX, the contractile responses to phenylephrine and 118 mM potassium were enhanced, and the basal release of nitric oxide decreased in the strips with endothelium compared with either OVX+E2 or control. An enhancement of contraction was also observed in the strips without endothelium. However, the extent of enhancement was smaller than that observed in the presence of endothelium. The simultaneous measurement of calcium ([Ca(2+)](i)) and tension revealed no significant difference in the [Ca(2+)](i) elevations induced by phenylephrine among the three groups. ...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T HayashiG Chaudhuri
Dec 15, 1988·Biochemical and Biophysical Research Communications·J NishimuraC van Breemen
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·C P WeinerS Moncada
Sep 1, 1995·Journal of Cellular Biochemistry·T CaloviniI Morano
Aug 15, 1996·The New England Journal of Medicine·F GrodsteinC H Hennekens
Jun 8, 1999·Current Opinion in Cardiology·R Brugada, R Roberts
Jul 6, 2000·British Journal of Pharmacology·Y ShintaniH Kanaide
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R J GonzalesN L Kanagy
Feb 15, 2001·American Journal of Physiology. Cell Physiology·R F Sánchez-OrtizS Chacko
Jun 20, 2001·American Journal of Hypertension·T Tolbert, S Oparil

❮ Previous
Next ❯

Citations

Feb 24, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Katsuya HiranoHideo Kanaide
Feb 7, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Yujia WangJiangping Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.