Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications

International Journal of Molecular Sciences
Kenichi Goto, Takanari Kitazono

Abstract

Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size vessels, and the hyperpolarization of vascular smooth muscle cells mediated by the endothelium plays a central role in agonist-mediated and flow-mediated vasodilation in resistance-size vessels. Although the mechanisms underlying diabetic vascular complications are multifactorial and complex, impairment of endothelium-dependent hyperpolarization (EDH) of vascular smooth muscle cells would contribute at least partly to the initiation and progression of microvascular complications of diabetes. In this review, we present the current knowledge about the pathophysiology and underlying mechanisms of impaired EDH in diabetes in animals and humans. We also discuss potential therapeutic approaches aimed at the prevention and restoration of EDH in diabetes.

References

Mar 1, 1997·The Journal of Clinical Investigation·J R RumbleR E Gilbert
Sep 2, 1999·Journal of Cardiovascular Pharmacology·P V KatakamA W Miller
Jan 4, 2001·European Journal of Pharmacology·S IidaK Kanmatsuse
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S J WiggH C Parkington
Jun 27, 2001·Free Radical Biology & Medicine·N E CameronM A Cotter
Mar 5, 2002·Journal of Hypertension·Yasuo KansuiMitsuo Iida
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tudor M GriffithDavid H Edwards
Sep 5, 2002·Journal of Cellular Physiology·Nour B BisharaMichael A Hill
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Eliana H AkamineZuleica B Fortes
Jul 26, 2003·Diabetes Research and Clinical Practice·Norman CameronMatthew Nangle
Dec 4, 2003·Biochemical and Biophysical Research Communications·Javier AnguloIñigo Sáenz de Tejada
Dec 9, 2003·Cardiovascular Research·Christy Lynn M Cooke, Sandra T Davidge
May 8, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Takayuki MatsumotoKatsuo Kamata
Nov 9, 2004·Journal of Diabetes and Its Complications·Kenro ImaedaMakoto Itoh

❮ Previous
Next ❯

Citations

Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Joshua M BockDarren P Casey
Aug 30, 2020·International Journal of Molecular Sciences·Nada A Sallam, Ismail Laher
Feb 3, 2021·International Journal of Molecular Sciences·Mirela LozićKatarina Vukojević
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Xuemei LiHuike Yang
Jul 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Oluwatobiloba OsikoyaStyliani Goulopoulou

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.