Endothelium-dependent inhibition of the contractile response is decreased in aorta from aged and spontaneously hypertensive rats

Archives of Medical Research
Maximiliano IbarraRafael Villalobos-Molina

Abstract

Stimulation of vascular 5-hydroxytryptamine-2C (5-HT(2c)) receptors produces contraction in rat aorta. We investigated the effect of aging on endothelium-dependent inhibition of contractile responses in thoracic aorta from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR). Endothelium-intact and denuded aortic rings were prepared from young (7-9 weeks old) and senescent (65-70 weeks old) WKY and SHR rats. Changes in isometric tension elicited by 5-HT, in the absence or in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME) or indomethacin were recorded. In aorta from WKY and SHR, 5-HT elicited concentration-dependent contractions, which were increased by endothelium removal. The ability of endothelium to depress contractile response to 5-HT was found to be reduced in vessels from senescent animals, mainly in SHR. L-NAME increased the sensitivity and maximal effect to 5-HT in endothelium-intact but not in denuded aortic rings from young WKY rats. The effect of L-NAME was lower in young SHR compared with age-matched WKY rats, but it did not modify the response to 5-HT in senescent rats. Indomethacin did not affect contraction in arteries from young WKY or in denuded aortic rings from young SHR and ...Continue Reading

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Citations

May 13, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Xin JinHiromu Kawasaki
Feb 7, 2014·Respiratory Research·Samantha GomartLaurence Dewachter
Jan 23, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Claudia Roberta de AndradeAna Maria de Oliveira
Nov 23, 2006·Experimental Gerontology·Carlos F Reyes-TosoDaniel P Cardinali
May 20, 2015·Canadian Journal of Physiology and Pharmacology·Jaime H Gómez-ZamudioMiguel Cruz
Mar 12, 2015·Canadian Journal of Physiology and Pharmacology·Elizabeth Alejandrina Guzmán-HernándezMaximiliano Ibarra-Barajas
Feb 13, 2018·Archives of Physiology and Biochemistry·Marko StojanovićMiroslav Radenković
Nov 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sylvain BattaultCyril Reboul

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