PMID: 7543395Jun 1, 1995Paper

Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats

Clinical Science
L Y DengE L Schiffrin

Abstract

1. Impaired endothelium-dependent relaxation has been previously demonstrated in blood vessels of hypertensive rats and in humans with essential hypertension. Arteries from spontaneously hypertensive rats have been shown to produce, in response to high concentrations of acetylcholine, a vasoconstrictor substance called endothelium-derived contracting factor, the production of which can be inhibited by indomethacin or other cyclo-oxygenase inhibitors, suggesting that it is a prostanoid. The mechanisms involved in endothelium-dependent relaxation of human arteries are unclear, and the potential generation of endothelium-derived contracting factor by endothelium in human hypertension has not been established. 2. We investigated the effects of acetylcholine on precontracted small arteries dissected from gluteal subcutaneous fat biopsies from normotensive subjects and subjects with borderline and mild essential hypertension. Vessels from normotensive subjects and those from borderline hypertensive patients, precontracted by noradrenaline, were relaxed completely by acetylcholine, whereas those from patients with mild essential hypertension relaxed slightly but significantly less, indicating that generation of endothelium-derived rel...Continue Reading

Citations

Nov 6, 2009·Clinical and Experimental Hypertension : CHE·Enzo PorteriEnrico Agabiti Rosei
Jul 24, 2001·The American Journal of the Medical Sciences·E L Schiffrin
May 1, 1997·British Journal of Pharmacology·I P FouyasI R Whittle
Jun 1, 1997·British Journal of Pharmacology·P OhlmannR Andriantsitohaina
Jan 1, 2007·Journal of the American Society of Hypertension : JASH·Ernesto L Schiffrin
Feb 28, 2009·Aging Cell·Leocadio Rodríguez-MañasCarlos F Sánchez-Ferrer
Jul 8, 2011·Basic & Clinical Pharmacology & Toxicology·Michael J Mulvany
Feb 20, 2010·American Journal of Hypertension·Haythem DebbabiBernard I Levy
Jan 23, 2010·American Journal of Hypertension·Enzo PorteriEnrico Agabiti Rosei
Apr 22, 2015·European Journal of Preventive Cardiology·Mohamed A Kader Abdel Wahab
Jan 30, 2008·Medical & Biological Engineering & Computing·Michael J Mulvany
Jan 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E L Schiffrin
Sep 12, 2000·Current Hypertension Reports·J B Park, E L Schiffrin
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Hanzhong LiuRichard Laverty
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ernesto L Schiffrin, Rhian M Touyz
Sep 16, 2000·Hypertension·A YoshidaH Kobayashi
Dec 29, 2011·Hypertension·Ernesto L Schiffrin
May 5, 2006·Fundamental & Clinical Pharmacology·Robinson JoannidesChristian Thuillez
Feb 23, 2011·The Open Cardiovascular Medicine Journal·Aamer SandooGeorge D Kitas
Mar 16, 2012·Interface Focus·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Jun 1, 1997·Journal of Hypertension·E L Schiffrin, D Hayoz
Jul 1, 1997·Journal of Cardiovascular Pharmacology·J S LiE L Schiffrin
Aug 31, 1999·Journal of Hypertension·P M Vanhoutte
Aug 13, 2002·Journal of Hypertension·Damiano Rizzoni
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·A W MillerM R Ujhelyi
Jan 29, 2002·Journal of Cardiovascular Pharmacology·E L Schiffrin
Apr 25, 2003·Canadian Journal of Physiology and Pharmacology·Ernesto L Schiffrin

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