Endothelium-dependent relaxations in sheep pulmonary arteries and veins: resistance to block by NG-nitro-L-arginine in pulmonary hypertension

British Journal of Pharmacology
B K KempT M Cocks

Abstract

1. The effect of the nitric oxide synthase inhibitor, NG-nitro-L-arginine (L-NOARG), on endothelium-dependent relaxation to a receptor-independent agent, ionomycin, was examined in isolated pulmonary arteries and veins from control, short-term and chronic pulmonary hypertensive sheep. All vessel segments were contracted to optimal levels of active force with endothelin-1 to record endothelium-dependent relaxation. 2. Pulmonary hypertension was induced by continuous pulmonary artery air embolization for 1 day (short-term) and 14 days (chronic) and was associated with a 2 and 3 fold increase in pulmonary vascular resistance respectively. 3. L-NOARG (0.1 mM) reduced the maximum relaxation (Rmax) to ionomycin in large and medium-sized pulmonary arteries from control sheep by approximately 70%. By contrast, L-NOARG (0.1 mM) did not inhibit the Rmax to ionomycin in matched vessels from short-term and chronic pulmonary hypertensive sheep. 4. Resistance of ionomycin-induced relaxations to inhibition by L-NOARG, was confined to the arterial vasculature in chronic pulmonary hypertensive animals, as relaxations to ionomycin in large and medium-sized chronic pulmonary hypertensive veins were, like those in control veins, abolished by L-NOA...Continue Reading

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Citations

Dec 22, 1999·British Journal of Pharmacology·F Pérez-VizcaínoJ Tamargo
Aug 2, 2005·British Journal of Pharmacology·Pierre-Yves von der Weid, Harold A Coleman
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C A HamiltonA F Dominiczak
Jan 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yuansheng Gao, J Usha Raj
May 26, 2005·Anesthesiology·Robert M BryanSean P Marrelli

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