PMID: 7515587May 11, 1994Paper

Endothelium-dependent relaxations to adenosine in juvenile rabbit pulmonary arteries and veins

The American Journal of Physiology
Robin H SteinhornJ A Russell

Abstract

We studied the actions of adenosine and its analogues 5'-(N-ethylcarboxamido)-adenosine (NECA) and N6-cyclohexyladenosine (CHA) in pulmonary vessels isolated from juvenile rabbits. Pulmonary arteries relaxed in a concentration-dependent fashion to all three compounds. Pretreatment with the methylxanthine 8-p-sulfophenyltheophylline shifted the concentration-response curves to adenosine and NECA rightward, indicating that the vasodilator effects were mediated by the adenosine receptor. The order of potency of adenosine compounds was NECA > adenosine > CHA, indicating that the A2-receptor mediates relaxations to adenosine in rabbit pulmonary arteries. Endothelium rubbing attenuated relaxations to adenosine at concentrations of < or = 3 x 10(-7) M and to all NECA concentrations. Inhibition of nitric oxide synthase with NG-nitro-L-arginine (L-NNA) similarly attenuated relaxations at concentrations of < or = 3 x 10(-7) M for adenosine and < or = 3 x 10(-8) M for NECA. With the use of the same methods, a substantial endothelial contribution was additionally observed in pulmonary veins to the vasodilator effects of NECA. We conclude that adenosine, and the more specific A2-receptor agonist NECA, dilate pulmonary arteries and veins iso...Continue Reading

Citations

Jan 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yuansheng Gao, J Usha Raj
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E P Silldorff, T L Pallone
Feb 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Girija G KonduriAshwani K Khanna
Sep 5, 2003·American Journal of Physiology. Renal Physiology·Pernille B Hansen, Jurgen Schnermann

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