Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine

Cardiovascular Research
E O McFallsP D Verdouw

Abstract

The aim as to compare the responses of intracoronary infusions of ATP, an endothelium dependent vasodilator, with adenosine following brief ischaemia (10 min) and reperfusion in a model of myocardial stunning. In group 1 (n = 6), coronary blood flow and endocardial (endo) and epicardial (epi) percent segment length shortening were measured in the distribution of the left anterior descending coronary artery before and during maximal intracoronary infusions of either adenosine or ATP (20 micrograms.kg-1.min-1). Measurements were obtained before and after myocardial stunning both at control heart rate and during atrial pacing (150 beats.min-1). In group 2 (n = 6), myocardial blood flows by microspheres and arterial-venous lactate and oxygen differences were determined following the same ischaemia-reperfusion protocol to characterise transmural changes in blood flow and metabolism in this model of stunning. The experiments were done on 12 anaesthetised swine, weight 25-39 kg. In group 1, baseline endo and epi segment length shortening were 16(SD 3)% and 14(6)% and following reperfusion were reduced to 10(4)% and 8(6)% respectively (p less than 0.05). Prior to stunning, minimal coronary resistances during adenosine and ATP were 0.81...Continue Reading

Citations

Jul 1, 1995·Basic Research in Cardiology·L C Becker
Nov 5, 1999·Archives of Pharmacal Research·W Y LeeS M Lee
Jan 31, 1997·International Journal of Cardiology·S R Maxwell, G Y Lip
Jun 1, 1997·Cardiovascular Research·J H van BlankensteinP D Verdouw
Sep 25, 1998·Cardiovascular Research·D J DunckerP D Verdouw
Jul 1, 1996·The Annals of Thoracic Surgery·M C MauneyC G Tribble

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