Endothelium-dependent vasodilatation is not selectively impaired in patients with chronic heart failure secondary to valvular heart disease and congenital heart disease

European Heart Journal
M NakamuraK Hiramori

Abstract

This study examined possible selective impairment of endothelial dysfunction in the peripheral vascular bed in patients with chronic heart failure in the absence of confounding factors influencing endothelial function (i.e. hypertension, hypercholesterolaemia and diabetes mellitus). Several recent studies have suggested that endothelium-dependent peripheral vasodilation is impaired but endothelium-independent vasodilation is preserved in patients with chronic heart failure. However, a classical paper has demonstrated that sodium nitrite-mediated calf blood flow is clearly depressed in patients with valvular heart disease and cardiomyopathy. We examined forearm blood flow changes mediated by acetylcholine and nitroprusside in patients with valvular heart disease (n = 55) or congenital heart disease (n = 13), and a comparison was made with healthy volunteers (n = 21). The blood flow changes mediated by acetylcholine and nitroprusside were significantly impaired in both patient groups (P < 0.01). When blood flow responses were collected from all patients, two types of vasodilatory capacity were found to have decreased significantly with increasing clinical severity of heart failure (New York Heart Association functional class; P <...Continue Reading

Citations

Nov 6, 2003·Sports Medicine·Andrew MaioranaDaniel Green
Apr 12, 2000·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·S MakitaK Hiramori
Nov 24, 2004·European Journal of Heart Failure·David R MorganGary E McVeigh
Jul 7, 2009·European Journal of Heart Failure·Magdalena KlosinskaMaria Krzeminska-Pakula
Sep 18, 2004·The Journal of Physiology·Daniel J GreenRoger Taylor
Sep 24, 1998·The American Journal of Physiology·A Cooper, A M Heagerty
Oct 16, 2015·Clinical Science·Paula K Bautista NiñoAnton J M Roks
Apr 10, 2003·Journal of Veterinary Internal Medicine·Henrik D PedersenAnnemarie T Kristensen
May 25, 2021·Journal of Cellular and Molecular Medicine·Boquan WuNaijin Zhang

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