Abstract
We recently showed that muscarinic receptor stimulation causes a marked increase in the net release of tissue-type plasminogen activator (TPA) antigen and activity across the human forearm in vivo, in conjunction with endothelium-dependent vasodilation. Because hypertension has been associated with endothelial dysfunction, the aim of the study was to compare forearm TPA release and vasodilation in response to muscarinic stimulation in normotensive (NC) and borderline hypertensive (BH) subjects. The study was performed in 10 apparently healthy young men with BH and 10 male NC subjects. Methacholine (MCh: 0.1, 0.8, and 4.0 micrograms/min) and sodium mitroprusside (SNP: 0.5, 2.5, and 10 micrograms/min) were administered in randomized order as double-blind, stepwise, intrabrachial artery infusions. Forearm blood flow was assessed by plethysmography. Net release/uptake was calculated as the product of the arteriovenous concentration gradient and forearm plasma flow. Vasodilator responses to MCh were similar in both groups (P = NS), whereas the decrease in forearm vascular resistance in response to SNP was somewhat less in BH subjects (P = .005). At rest, both groups showed a significant arteriovenous gradient and net release of TPA ...Continue Reading
References
Sep 1, 1978·Thrombosis Research·D R RosingS E Epstein
Jan 1, 1979·Thrombosis Research·H P Klöcking
Nov 7, 1992·Lancet·D S CelermajerJ E Deanfield
Jun 1, 1992·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S H DondersJ W van Wersch
Dec 1, 1992·The Journal of Clinical Investigation·A CalverP Vallance
Mar 24, 1992·European Journal of Pharmacology·N Tranquille, J J Emeis
Jan 1, 1992·Acta Haematologica·N ArikS Caĝlar
Feb 1, 1991·American Journal of Hypertension·G Gleerup, K Winther
Apr 1, 1991·Journal of Internal Medicine·J H JanssonT K Nilsson
May 1, 1990·Journal of Cellular Physiology·S L DiamondS G Eskin
Apr 1, 1990·Journal of Internal Medicine·K LandinU Smith
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Jul 16, 1990·Biochemical and Biophysical Research Communications·M U NollertL V McIntire
Mar 17, 1989·Science·S L DiamondL V McIntire
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A PalermoA Libretti
Oct 28, 1989·Lancet·P VallanceS Moncada
Jul 1, 1987·Psychophysiology·M W Vasey, J F Thayer
Sep 1, 1985·Hypertension·C P LucasG M Reaven
Nov 27, 1980·Nature·R F Furchgott, J V Zawadzki
May 1, 1983·Thrombosis Research·J J Emeis
Nov 1, 1993·Annals of Surgery·M G Davies, P O Hagen
Dec 23, 1993·The New England Journal of Medicine·A SagieD Levy
Oct 1, 1993·European Heart Journal·A BergbrantS Jern
Aug 1, 1993·Journal of Internal Medicine·A BergbrantS Jern
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N ResnickM A Gimbrone
Jul 1, 1968·American Journal of Epidemiology·R S PaffenbargerA L Wing
Jul 1, 1953·The Journal of Physiology·R J WHITNEY
May 1, 1964·Journal of Chronic Diseases·S JULIUSS W HOOBLER
Citations
Aug 7, 2007·European Journal of Applied Physiology·Tracy BaynardBo Fernhall
Sep 18, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D MiljicV Popovic
Sep 26, 2002·Thrombosis Research·Neda DovjakDusan Keber
Aug 31, 1999·Journal of Hypertension·P M Vanhoutte
Feb 2, 2013·Sleep·Brian R WeilChristopher A Desouza
Jan 9, 2015·Journal of Human Hypertension·K J DiehlC A DeSouza
Sep 8, 2007·Advanced Drug Delivery Reviews·Erhard Haus
May 4, 1999·Angiology·G Dell'OmoR Pedrinelli
Jun 30, 2005·American Journal of Physiology. Endocrinology and Metabolism·Gary P Van GuilderChristopher A DeSouza
Jan 2, 2003·The Journal of Physiology·Derek T SmithChristopher A DeSouza
Jun 20, 2003·The Journal of Physiology·Greta L HoetzerChristopher A DeSouza
Nov 20, 2004·Journal of Thrombosis and Haemostasis : JTH·T HrafnkelsdottirS Jern
Oct 26, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gary P Van GuilderChristopher A DeSouza
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Greta L HoetzerChristopher A DeSouza
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·W Kiowski
Apr 25, 2000·American Journal of Hypertension·R PedrinelliM Mariani
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S Bertuglia, A Colantuoni
Jul 24, 2014·The American Journal of Cardiology·Caitlin A DowChristopher A DeSouza
Sep 6, 2011·The American Journal of Cardiology·Brian R WeilBrian L Stauffer
Sep 13, 2002·Journal of the American College of Cardiology·James A Muldowney, Douglas E Vaughan
Sep 8, 2021·Hypertension·Kelly A StockelmanChristopher A DeSouza