PMID: 9420631Oct 1, 1994Paper

Endothelium-dependent vasodilation of peripheral conduit arteries in patients with heart failure

Journal of Cardiac Failure
A J BankS H Kubo

Abstract

Endothelium-dependent vasodilation of peripheral resistance vessels is abnormal in patients with heart failure, but there are little in vivo data on endothelium-dependent vasodilation of peripheral conduit vessels. This study assessed endothelium-dependent vasodilation of forearm conduit and resistance vessels in normal subjects and patients with heart failure. The effects of intraarterial endothelium-dependent and endothelium-independent vasodilators on both forearm conduit (brachial artery) and resistance vessels were assessed in 9 patients with New York Heart Association class II-III heart failure and 11 normal subjects of similar age. Brachial artery diameter was measured by two-dimensional, moderate-frequency (8 MHz) ultrasound, and forearm blood flow was measured by strain gauge plethysmography. The endothelium-dependent vasodilator, methacholine (0.3 and 1.5 micrograms/min), increased brachial artery diameter by 7.6 +/- 1.3% and 12.2 +/- 1.5% in normal subjects as compared to 6.9 +/- 2.1% and 10.4 +/- 2.4% in patients with heart failure (P = NS, normal vs heart failure). The endothelium-independent vasodilator, nitroglycerin (0.15 microgram), also produced similar increases in brachial artery diameter in the two groups (...Continue Reading

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Citations

Nov 24, 1995·The American Journal of Cardiology·J N Cohn
Apr 21, 1998·Journal of Cardiac Failure·M J CrespoN Escobales
Oct 12, 2000·IEEE Transactions on Medical Imaging·L FanD M Herrington
Aug 23, 2006·Industrial Health·Yoshi-ichiro Kamijo, Hiroshi Nose
Oct 13, 2006·The International Journal of Cardiovascular Imaging·Eugenio PicanoEliseo Vano
Sep 11, 2014·Journal of Health Communication·Danielle A Naugle, Robert C Hornik

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