PMID: 7545773Jan 1, 1995Paper

Endothelium-dependent vasorelaxant effect of trilinolein: mediated by nitric oxide and cyclic GMP

Life Sciences
C Y HongY T Huang

Abstract

At concentrations ranged from 0.1 nM to 1 microM, trilinolein concentration-dependently relaxed the phenylephrine-induced constriction of isolated rat aorta. Concentration-response curves for the interaction between trilinolein and phenylephrine showed that trilinolein was unlikely a competitive antagonist of phenylephrine. The vasorelaxant effect of trilinolein was dependent on the presence of intact endothelium. Both NG-nitro-L-arginine methyl ester and methylene blue antagonized this vasorelaxant effect. L-arginine partially reversed the effect of L-NAME on trilinolein. Linoleic acid had no vasorelaxant effect. We concluded that trilinolein is an endothelium dependent vasorelaxant and the underlying mechanism could be a stimulation of the nitric oxide and cyclic GMP pathway.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Nov 1, 1994·Thrombosis Research·L J LaiC Y Hong
May 14, 1994·Lancet·E Anggård
Jul 1, 1994·Trends in Pharmacological Sciences·R Schulz, C R Triggle

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Citations

Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Francis I Achike, Chiu-Yin Kwan
Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·C Y HongC F Kwok
Jun 11, 2002·Annual Review of Nutrition·Guoyao Wu, Cynthia J Meininger
Feb 18, 2003·Fundamental & Clinical Pharmacology·Fatmah Bibi Housnah Gurib, Anwar Hussein Subratty
Nov 18, 2006·Canadian Journal of Physiology and Pharmacology·J Robert McNeill, Tannis M Jurgens
Dec 22, 1999·British Journal of Pharmacology·F Pérez-VizcaínoJ Tamargo

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