Endothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein grafts

Journal of Vascular Surgery
K KomoriP M Vanhoutte

Abstract

The endothelium releases factor(s) that are potent vasodilators and inhibitors of platelet aggregation. Experiments were performed to determine whether the endothelium-dependent responses to aggregating platelets are altered in vein grafts. Segments of jugular veins were grafted in the reverse position into the carotid arteries in 16 rabbits. After 4 weeks the patent grafts (14 of 16) were removed, and the endothelium-dependent responses were examined in vitro. In control veins aggregating platelets, adenosine diphosphate, and serotonin caused endothelium-dependent relaxations. The platelet-induced relaxations were attenuated by apyrase (adenosine diphosphatase and adenosine triphosphatase) but not by methiothepin (serotonergic blocker). In vein grafts, endothelium-dependent relaxations in response to aggregating platelets were absent, and only contractions that could be attenuated by methiothepin were observed. In vein grafts, endothelium-dependent relaxations in response to adenosine diphosphate were reduced, and only endothelium-independent contractions were observed in response to serotonin. These contractions were attenuated by methiothepin. These results suggest that (1) the endothelium exerts an inhibitory effects mediat...Continue Reading

Citations

Jan 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charles J DiskinThomas B Carter
Jul 6, 2012·The Journal of Surgical Research·Fan Dong LiPadmini Komalavilas
Apr 17, 2012·Nitric Oxide : Biology and Chemistry·Matthew J AlefBrian S Zuckerbraun
Apr 9, 2008·The Journal of Surgical Research·Hiromine FujitaKimihiro Komori
Feb 24, 2009·Journal of Vascular Surgery·Akio KodamaTakeo Itoh
Jun 13, 2006·Journal of Vascular Surgery·Tadashi FuruyamaYoshihiko Maehara
Feb 19, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K KomoriK Sugimachi
Aug 4, 2012·Journal of Vascular Surgery·Takashi MaekawaTakeo Itoh
Apr 24, 2018·Annals of Vascular Diseases·Paul M Vanhoutte

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