PMID: 7524060Jun 1, 1994Paper

Endothelium-derived relaxing factor and cyclic GMP-dependent vasorelaxation in human chorionic plate arteries

Placenta
A D HullW J Pearce

Abstract

Endothelium derived relaxing factor (EDRF), now widely believed to be nitric oxide (NO), may play an important part in the control of fetoplacental vascular tone. To further explore this role we have determined the relaxation responses to exogenous NO and examined the temporal relationship between intracellular concentrations of cyclic GMP and vascular tone in isolated ring segments of human chorionic plate arteries. We have also determined the dose relations for the contractile agonists serotonin and the thromboxane analog U46619. Lastly, we have explored the relaxation responses to a wide range of agents known to elicit EDRF release in other vascular beds. Chorionic plate arteries relaxed significantly to exogenous NO with concomitant increases in cyclic guanosine monophosphate over basal values. ED50s for serotonin and U46619 were 1.48 x 10(-6) M and 3.39 x 10(-8) M respectively. The ED50 for NO derived from S-nitroso-N-acetyl-penicillamine was 1.28 x 10(-6) M. Endothelium-intact segments of chorionic plate arteries pre-contracted with either serotonin or U46619 failed to relax significantly to acetylcholine, adenosine diphosphate, A23187, bradykinin, and histamine and only minimally to substance P. We suggest that EDRF is l...Continue Reading

References

Feb 1, 1991·British Journal of Pharmacology·G ChaudhuriL J Ignarro
Feb 1, 1991·American Journal of Obstetrics and Gynecology·L MyattD E Brockman
Jan 1, 1991·Reproduction, Fertility, and Development·R G KingT J Rook
Apr 1, 1990·Journal of Cellular Physiology·J A HollandM B Stemerman
Jan 1, 1989·Pharmacology & Therapeutics·T M Lincoln
Apr 1, 1987·Circulation Research·J Van de VoordeI Leusen
Jan 1, 1958·The Journal of Pathology and Bacteriology·J C POOLEH W FLOREY

❮ Previous
Next ❯

Citations

Mar 4, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A H ShaamashH M EL-dien
Mar 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R Di IorioE V Cosmi
Sep 1, 1995·British Journal of Obstetrics and Gynaecology·N H MorrisP J Steer
Jan 1, 1996·British Journal of Obstetrics and Gynaecology·N H MorrisG Dekker
Jul 16, 2010·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Aleksandar JurisićSvetlana Dragojević-Dikić
Nov 30, 2000·Placenta·B E McLaughlinJ F Brien
Apr 25, 2001·Biology of Reproduction·C SheppardR R Magness
Mar 9, 2018·Science Translational Medicine·Chloe R McDonaldKevin C Kain
Mar 7, 2002·American Journal of Physiology. Cell Physiology·Tatsuya TakizawaHidetoshi Morita
Apr 6, 2019·Current Pharmaceutical Design·Emilie HitzerdA H Jan Danser
Apr 1, 1999·Human & Experimental Toxicology·D E Holt, R Bajoria
Jan 1, 1996·Pediatric Research·C R White, W J Pearce

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.