PMID: 7529399Oct 1, 1994Paper

Endothelium derived relaxing factor is involved in the pressure control of renin gene expression in the kidney

Pflügers Archiv : European journal of physiology
K SchrickerA Kurtz

Abstract

To study the influence of endothelium derived relaxing factor/nitric oxide (EDNO) on renin gene expression, the effects of a 2-day treatment with the NO-synthase inhibitor nitro-L-arginine-methylester (L-NAME, 40 mg/kg twice a day) on plasma renin activity (PRA) and renal and adrenal renin m-RNA levels were examined in conscious rats with and without unilateral renal clips (0.2 mm). In sham-clipped animals L-NAME led to a decrease of PRA from 7.5 to 2.5 ng angiotensin (ANGI).h-1.ml-1 and to a 35% decrease of renal renin m-RNA levels. Unilateral renal artery clipping increased PRA to 35 and to 13 ng ANGI.h-1.ml-1 in vehicle and in L-NAME-treated rats, respectively. In the clipped kidneys renin m-RNA levels increased to 450% of control values in vehicle-treated animals and to 220% of control values in L-NAME-treated animals. In the contralaterals as opposed to clipped kidneys, renin m-RNA levels decreased to 16% and 50% of the control values in vehicle- and in L-NAME-treated animals, respectively. In the adrenal glands renin m-RNA levels were not significantly changed either by clipping of one renal artery or by treatment of animals with L-NAME. The NO-donor sodium nitroprusside (100 microM) was found to increase renin secretion ...Continue Reading

References

Oct 1, 1992·Kidney International·P MundelW Kriz
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S WilcoxH H Schmidt
Dec 1, 1992·Clinical and Experimental Pharmacology & Physiology·Y ZhangG Read
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Oct 1, 1991·The Journal of Clinical Investigation·A KurtzW Baier
Feb 1, 1992·Hypertension·W H Beierwaltes, O A Carretero
Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·K Münter, E Hackenthal
Oct 1, 1990·Physiological Reviews·E HackenthalR Taugner
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C E BurnhamK R Lynch
May 10, 1988·European Journal of Pharmacology·M J VidalP M Vanhoutte
Oct 1, 1988·Hypertension·S C MakridesH Gavras
Jun 1, 1987·Hypertension·V J DzauJ R Ingelfinger
Jul 1, 1993·Acta Physiologica Scandinavica·C ThorupA E Persson
Jun 1, 1993·Acta Physiologica Scandinavica·P A NaessF Kiil

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Citations

Jun 1, 1995·Pflügers Archiv : European journal of physiology·K SchrickerA Kurtz
Jun 1, 1996·Pflügers Archiv : European journal of physiology·K Schricker, A Kurtz
Dec 1, 1995·Clinical and Experimental Pharmacology & Physiology·B J Morris
Jul 1, 1997·Clinical and Experimental Pharmacology & Physiology·A Kurtz
Jan 1, 1995·Fundamental & Clinical Pharmacology·I A Reid, Y J Chiu
Oct 8, 1999·Clinical and Experimental Hypertension : CHE·Y J ChiuI A Reid
Jul 24, 2010·American Journal of Hypertension·Johan SällströmA Erik G Persson
Mar 3, 2007·Pharmacological Reviews·Noboru TodaTomio Okamura
Jul 1, 1996·Pflügers Archiv : European journal of physiology·K SchrickerA Kurtz
Oct 31, 1998·Journal of Hypertension·A Sánchez-MendozaB Escalante
Dec 9, 1998·The American Journal of Physiology·A Kurtz, C Wagner

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