Endothelium-derived relaxing factor: presence in pulmonary and systemic arteries of the newborn guinea pig

Pediatric Research
D Davidson, A Eldemerdash

Abstract

Endothelium-derived relaxing factor (EDRF), believed to be nitric oxide or a compound that releases nitric oxide, is a potent vasodilator produced by some arteries in response to acetylcholine (ACh) and bradykinin (BK). ACh and BK are potent dilators of perinatal pulmonary and systemic arteries. The objectives of this study were to determine if EDRF is present in newborn vessels and if EDRF mediates the vasodilator actions of ACh and BK. Arterial rings from newborn guinea pigs, 1 to 3 d old, were obtained from a branch of the main pulmonary artery and the descending aorta for isometric force bioassays. At their optimal resting tension, the rings were preconstricted with phenylephrine 10(-5) M in Krebs-Henseleit solution before adding incremental doses of ACh or BK. If the endothelium was intact, ACh (10(-5) M) relaxed pulmonary arteries and aortas (64 +/- 7%, 72 +/- 9% relaxation, respectively, mean +/- SE). ACh-induced relaxation (ACh 10(-5) M) in the pulmonary artery and aorta, respectively, was significantly (p less than 0.05) attenuated by 1) endothelial removal (11 +/- 9%, 28 +/- 10%) by rubbing the ring lumen; 2) methylene blue, 10(-6) M, (6 +/- 8%, 7 +/- 3%) that inhibits EDRF-associated cGMP production in smooth muscle;...Continue Reading

Citations

Oct 21, 2000·European Journal of Pharmacology·B D HegartyE R Lumbers
Apr 1, 1997·Mechanisms of Ageing and Development·J Török, M Gerová
Jul 1, 1996·International Journal of Obstetric Anesthesia·D Davidson
Jun 1, 1992·British Journal of Pharmacology·S F LiuP J Barnes
Jul 11, 1998·Archives of Disease in Childhood·P S DaviesN D Barnes
Jan 1, 1995·Mediators of Inflammation·M R PierceM J Miller
Feb 1, 1992·American Journal of Obstetrics and Gynecology·J K ChangM A Heymann
Oct 20, 2007·Acta Anaesthesiologica Scandinavica·P L LinC H Huang
Dec 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·S C BodyW E Hurford
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P S Davies
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judy L AschnerMamta Fuloria
Nov 18, 2000·British Journal of Pharmacology·K ImaedaH Suzuki
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R FritscheB Pelster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.