PMID: 2117136Jan 1, 1990Paper

Endothelium-derived relaxing factors and the human pulmonary circulation

Lung
D McCormack

Abstract

The vasodilator effect of acetylcholine on the pulmonary circulation was first described over 30 years ago, however, the mechanism remained unknown until Furchgott described the endothelium-dependent relaxation of certain vasodilators. It was not until 1987 that endothelium-derived relaxant factor (EDRF) was demonstrated to dilate human pulmonary arteries in vitro. Despite this work, the physiologic role of EDRF in the pulmonary circulation is not known. It has been suggested that hypoxia-induced inhibition of EDRF action or release from pulmonary artery endothelial cells may have a role in hypoxic pulmonary vasoconstriction (HPV) but present evidence suggests that loss of EDRF activity is not directly involved in the phenomenon of HPV. It is more likely that EDRF is released from pulmonary artery endothelial cells during hypoxia and this released EDRF then modulates HPV. If EDRF does modulate HPV in vivo then the role of EDRF in the altered HPV found in disease merits attention. It is known that in disease states such as acute lung injury and pneumonia there is loss or attenuation of HPV which inevitably leads to increased V/Q mismatch and hypoxemia. Whether this attenuation of HPV is due to release of an endogenous vasodilato...Continue Reading

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Citations

May 1, 1991·Journal of Cellular Biochemistry·G M Rubanyi
Jan 1, 1994·Medicinal Research Reviews·J F Kerwin, M Heller
May 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·E Glusa, M Richter
Jan 1, 1992·Pharmacology & Therapeutics·F M Faraci
Jan 1, 1996·Free Radical Biology & Medicine·Z S Katusic
Oct 17, 2002·Vascular Pharmacology·Gabor M RubanyiKatalin Kauser
Nov 1, 1996·Journal of Cardiovascular Pharmacology·E IsotaniK Hirakawa
Dec 1, 1993·British Journal of Pharmacology·J F KlehaA Johns
Apr 1, 1994·The Journal of Pharmacy and Pharmacology·A M Gurney
Jan 1, 1997·Annual Review of Physiology·B NiliusG Droogmans
Jan 1, 1992·Critical Reviews in Toxicology·D W WilsonD Morin
Aug 1, 1992·The Anatomical Record·S AharinejadW Firbas
Jan 1, 1991·Law, Medicine & Health Care : a Publication of the American Society of Law & Medicine·C Levine, G L Stein
Oct 1, 1995·Journal of Molecular and Cellular Cardiology·M KitakazeT Kamada

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