Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure

British Journal of Pharmacology
C ForsterP Armstrong

Abstract

1. The relaxant actions of nitroglycerin (previously considered to be an endothelium-independent relaxing agent) and acetylcholine (an endothelium-dependent relaxing agent) were compared on 4 vascular preparations (dorsal pedal artery, saphenous vein, left anterior descending coronary artery and circumflex coronary artery) from dogs with and without pacing-induced congestive heart failure (CHF). 2. Responses of the coronary arteries to acetylcholine were unaltered in endothelium-intact rings from dogs with and without heart failure. Similarly no such changes were observed in the peripheral vessels. The maximum relaxation produced by acetylcholine was always greater in the coronary vessels compared to the peripheral vessels. 3. Before heart failure, the coronary vessels were more sensitive and reactive to nitroglycerin compared to the peripheral vessels. 4. Removal of the endothelium in both the control (dogs without CHF) and experimental (dogs with CHF) rings enhanced the relaxant effects of nitroglycerin, such that the EC50 for nitroglycerin became significantly lower in all denuded rings, with the exception of the saphenous vein and the left anterior descending coronary artery, before the development of CHF. 5. When CHF was m...Continue Reading

References

Jan 1, 1978·International Anesthesiology Clinics·J B Stetson
Oct 1, 1978·American Heart Journal·J E Cottrell, H Turndorf
Apr 1, 1987·Journal of Cardiovascular Pharmacology·A AbdollahP W Armstrong
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Citations

Aug 6, 1991·European Journal of Pharmacology·C ForsterP W Armstrong
Aug 1, 1993·Journal of the American College of Cardiology·J R TeerlinkJ P Clozel
Dec 30, 1996·European Journal of Pharmacology·G Larosa, C Forster
Dec 31, 2011·Circulation Research·Matteo BerettaBernd Mayer
Apr 1, 1992·Circulation·R I Ogilvie, D Zborowska-Sluis
Jun 11, 1999·The American Journal of Physiology·T MatsumotoM Kinoshita

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