Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling

Journal of Molecular and Cellular Cardiology
Qinshuo ZhaoChunxia Zhao

Abstract

Myocardial infarction (MI) contributes to the development of cardiac remodeling and heart failure. Insufficient post-MI myocardial angiogenesis has been identified as a non-negligible event which precipitates heart failure progression. Previous studies reported that cytochrome P450 epoxygenase and its metabolites exerted beneficial effects on cardiovascular diseases. However, the role of cytochrome P450 2J2 (CYP2J2) in post-MI heart failure is incompletely understood. First, western blot and real-time PCR analyses showed that CYP2J2 expression increased clearly in patients with acute MI and old MI, compared to control. Second, echocardiography and histological studies showed that transgenic (TG) rats had relatively preserved cardiac function, as well as attenuated remodeling, and reduced scar formation, compared to the wild-type (WT) littermates after MI eight weeks. Importantly, the cardioprotective effect induced by CYP2J2 overexpression was abrogated by VEGFR2 inhibitor-cediranib. More intriguingly, positron emission computed Tomography (PET) analyses showed that TG rats displayed better myocardial perfusion than WT rats. We found that these effects were linked to increasing circulating EETs and enhancing myocardial angiogen...Continue Reading

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Citations

Jul 12, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jingqiu HuangHong Zhang
Sep 4, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jian LuXin Wang
Feb 28, 2021·Signal Transduction and Targeted Therapy·Bei WangDao Wen Wang
Mar 16, 2021·Frontiers in Physiology·Jinsheng Lai, Chen Chen
Jun 15, 2020·Pharmacology & Therapeutics·Aditi DasHannah C Huff

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