PMID: 8942331Oct 1, 1996Paper

Endotoxaemia and postoperative hypermetabolism in coronary artery bypass surgery: the role of ketanserin

British Journal of Anaesthesia
H M Oudemans-van StraatenL Eijsman

Abstract

In a randomized, double-blind clinical study in 29 patients undergoing elective coronary artery surgery, we assessed the role of ketanserin, an inhibitor of serotonin-induced vasoconstriction and weak alpha 1 sympathetic blocker, in reducing endotoxaemia and postoperative hypermetabolism. Male patients without major organ dysfunction were allocated randomly to receive either ketanserin or placebo. Hypermetabolism was defined as an increase in oxygen consumption in the early postoperative hours (delta Vo2). Circulating endotoxin (P = 0.04) and postoperative delta Vo2 (P = 0.03) were lower in the ketanserin patients. Endotoxaemia was associated also with low vascular filling. From these preliminary results we conclude that treatment with ketanserin during cardiac surgery may reduce but not abolish endotoxaemia and postoperative hypermetabolism.

Citations

Aug 13, 2015·Journal of Critical Care·Namkje A R VellingaE Christiaan Boerma
Jul 25, 2009·The Journal of Surgical Research·Gang ChenDavid J Bouchier-Hayes
Dec 9, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Paul W G ElbersCan Ince
May 7, 1999·Journal of Cardiothoracic and Vascular Anesthesia·E HammarénM Hynynen
Feb 27, 2003·The Australian Journal of Rural Health·Fleur HourihanTimothy Chen
Dec 3, 2003·Intensive Care Medicine·Peter E SpronkCan Ince

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