Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: A randomized crossover double-blind study

PloS One
Marcus BromanMikael Bodelsson

Abstract

Endotoxin induces an inflammatory response, with secondary release of cytokines, which can progress to shock and multiple organ failure. We explored whether continuous renal replacement therapy (CRRT) using a modified membrane (oXiris) capable of adsorption could reduce endotoxin and cytokine levels in septic patients. Sixteen patients requiring CRRT for septic shock-associated acute renal failure and who had endotoxin levels >0.03 EU/ml were prospectively randomized in a crossover double-blind design to receive CRRT with an oXiris filter or with a standard filter. Endotoxin and cytokine levels were measured at baseline and 1, 3, 8, 16 and 24 hours after the start of CRRT. Norepinephrine infusion rate and blood lactate levels were monitored. During the first filter treatment period, endotoxin levels decreased in 7 of 9 (77.8%) oXiris filter patients, but in only 1 of 6 (16.7%) standard filter patients (P = 0.02). Levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8 and interferon (IFN)γ decreased more with the oXiris filter than with the standard filter. Lactate concentration decreased with oXiris (-1.3[-2.2 to -1.1] mmol/l, P = 0.02), but not with the standard filter (+0.15[-0.95 to 0.6]). The norepinephrine infus...Continue Reading

References

Jan 1, 1991·Chest·R L DannerJ E Parillo
Feb 1, 1991·Journal of Biochemical and Biophysical Methods·J KambayashiS Matsuura
Feb 19, 2000·Current Opinion in Microbiology·B Beutler
Aug 3, 2000·Intensive Care Medicine·C VenetJ C Bertrand
Dec 20, 2002·Nature·Jonathan Cohen
Jul 10, 2004·The Journal of Infectious Diseases·John C MarshallUNKNOWN MEDIC study
Feb 25, 2009·Critical Care Medicine·Didier PayenUNKNOWN Hemofiltration and Sepsis Group of the Collège National de Réanimation et de Médecine d'Urgence des Hôpitaux extra-Universit
May 15, 2009·Scandinavian Journal of Immunology·A CastellheimT E Mollnes
Jun 18, 2009·JAMA : the Journal of the American Medical Association·Dinna N CruzClaudio Ronco
Mar 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Thomas Rimmelé, John A Kellum
Sep 7, 2011·Blood Purification·T I Ala-KokkoJ Koskenkari
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Jul 20, 2013·Renal Failure·Rafidah AtanRinaldo Bellomo
Sep 26, 2013·Indian Journal of Medical Microbiology·C Vaishnavi
Jan 19, 2017·Critical Care Medicine·Andrew RhodesR Phillip Dellinger
May 8, 2018·Intensive Care Medicine Experimental·Benjamin MalardJohn A Kellum
Oct 12, 2018·JAMA : the Journal of the American Medical Association·R Phillip DellingerUNKNOWN EUPHRATES Trial Investigators
May 16, 2019·Annals of Intensive Care·Patrick M HonoreLui G Forni

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Citations

Aug 12, 2020·Artificial Organs·Shaohao FengminQiying Fang
Sep 9, 2020·Der Internist·B SeeligerSascha David
Feb 26, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·W Huber, A P Ruiz de Garibay
Apr 10, 2020·Acta Anaesthesiologica Scandinavica·Viveka BjörckMikael Bodelsson
Mar 8, 2020·Annals of Intensive Care·Ayman Karkar, Claudio Ronco
Jul 25, 2020·Nature Reviews. Nephrology·Balazs Szamosfalvi, Lenar Yessayan
Oct 14, 2020·Critical Care : the Official Journal of the Critical Care Forum·Gianluca VillaClaudio Ronco
Nov 18, 2020·The Journal of Critical Care Medicine·Judit Kovacs
Jan 19, 2021·Revista española de anestesiología y reanimación·R García-HernándezUNKNOWN en nombre del GRUPO DE INVESTIGACIÓN CONVEHY®
Jan 21, 2021·Current Opinion in Anaesthesiology·Salvatore Lucio CutuliMassimo Antonelli
Mar 13, 2021·Seminars in Dialysis·Claudio Ronco, Thiago Reis
Jun 3, 2021·Medicina·Salvatore Lucio CutuliGennaro De Pascale
Aug 15, 2021·Advances in Chronic Kidney Disease·Balazs SzamosfalviLenar Yessayan
Sep 15, 2021·The Cochrane Database of Systematic Reviews·Yasushi TsujimotoTomoko Fujii
Sep 7, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Vedran PremužićSlobodan Mihaljević
Sep 29, 2021·Current Opinion in Critical Care·Ying FengZhiyong Peng
May 10, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·ZhiJiang ChenQiyi Zeng

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