PMID: 8589356Jan 1, 1995Paper

Endotoxin induced cellular communication in the liver: murine models for clarification of the role of LPS-responsive macrophages in the pathogenesis of liver diseases

Journal of Gastroenterology and Hepatology
Y ShiratoriM Omata

Abstract

In several experimental models, lipopolysaccharide (LPS) plays an important role in the pathogenesis of liver diseases. Murine models of C3H/HeN and C3H/HeJ mice have been used to elucidate the role of LPS and its responsive-macrophages in vivo, as C3H/HeN strain mice are known to be LPS-responsive, while C3H/HeJ strain mice are LPS-resistant. Furthermore, release of several kinds of biologically active mediators such as interleukin-1, tumour necrosis factor-alpha, colony stimulating factor and reactive oxygen radical is not enhanced in C3H/HeJ mice even after stimulation with LPS. Thus, these murine models could be suitable for clarification of endotoxin induced cellular communication in the liver.

References

Mar 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·P TanapetJ D Broome
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G K Michalopoulos, R Zarnegav
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Y Scoazec, G Feldmann
Sep 11, 1990·European Journal of Biochemistry·K Decker
Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R P CornellK F Bartizal
Nov 1, 1990·Seminars in Liver Disease·D L Laskin
Feb 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriT Sugimoto
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H Van BossuytE Wisse
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriK Kamii
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F KatsumotoF Nakayama
Jun 16, 1988·Biochemical and Biophysical Research Communications·K R FeingoldC Grunfeld
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S GillardA Kirn
Jan 1, 1982·Endeavour·D L Knook
Jun 1, 1982·Experimental Cell Research·D L KnookA M de Leeuw
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K VanderkerkenE Wisse
Feb 1, 1993·Seminars in Liver Disease·A D BurtP Bioulac-Sage

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Citations

Apr 13, 2011·World Journal of Gastroenterology : WJG·Michael AdlerMichael Poles
Jan 18, 2006·Chinese Journal of Digestive Diseases·Xiong Ma, Zhiping Li
Dec 15, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ji-Ye LimDae-Ki Kim

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