Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer

British Journal of Pharmacology
G FolkertsF P Nijkamp


1. Pretreatment of guinea-pigs with endotoxin (1 mg kg-1 b.w., i.p., 4 days before the experiments) results in respiratory airway hyperreactivity in vitro. Dose-response curves with either arecoline or histamine on isolated tracheae from these animals display increased maximal contractions, and decreased EC50 values. 2. Tracheae denuded of epithelium respond with a similar hyperreactivity to histamine as observed in preparations from endotoxin pretreated animals. Removal of the epithelial layer of tracheae from endotoxin pretreated guinea-pigs did not additionally affect the histamine dose-response curve. 3. The cyclo-oxygenase inhibitor indomethacin (10 microM) induces histamine hyperreactivity which is equal in intact and epithelium-denuded tracheae from saline or endotoxin pretreated guinea-pigs. Similar results are obtained with the combined lipoxygenase/cyclo-oxygenase inhibitor nordihydroguaiaretic acid (10 microM). 4. Histamine (0.1 mM) induces an increase in prostaglandin E2 (PGE2) formation by the tracheal spiral in vitro, which is reduced by 34% by endotoxin pretreatment, and by about 60% following epithelium removal irrespective of endotoxin pretreatment. 5. Arachidonic acid (AA, 22 microM) stimulation of the guinea-...Continue Reading


Apr 21, 1977·The New England Journal of Medicine·A A MathéC A Leslie
Feb 1, 1975·The Journal of Pharmacy and Pharmacology·L GrodzinskaR J Gryglewski
Apr 14, 1977·The New England Journal of Medicine·A A MathéC A Leslie
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·L SteelM Kaliner
Jan 1, 1975·International Archives of Allergy and Applied Immunology·W Dawson, W J Sweatman
Jun 1, 1988·The American Review of Respiratory Disease·G FolkertsF P Nijkamp
Jan 1, 1988·British Journal of Pharmacology·H AizawaM Tomooka
Dec 10, 1985·European Journal of Pharmacology·G Folkerts, F P Nijkamp
Nov 1, 1985·Seminars in Arthritis and Rheumatism·E C KuJ Tjan
Mar 1, 1985·Journal of Applied Physiology·N A FlavahanP M Vanhoutte
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Nov 1, 1985·British Journal of Pharmacology·P J BarnesJ B Palmer
Sep 19, 1973·Nature: New Biology·J OrehekA Bouhuys
Jan 28, 1983·European Journal of Pharmacology·A J SchreursF P Nijkamp

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