Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer

British Journal of Pharmacology
G FolkertsF P Nijkamp

Abstract

1. Pretreatment of guinea-pigs with endotoxin (1 mg kg-1 b.w., i.p., 4 days before the experiments) results in respiratory airway hyperreactivity in vitro. Dose-response curves with either arecoline or histamine on isolated tracheae from these animals display increased maximal contractions, and decreased EC50 values. 2. Tracheae denuded of epithelium respond with a similar hyperreactivity to histamine as observed in preparations from endotoxin pretreated animals. Removal of the epithelial layer of tracheae from endotoxin pretreated guinea-pigs did not additionally affect the histamine dose-response curve. 3. The cyclo-oxygenase inhibitor indomethacin (10 microM) induces histamine hyperreactivity which is equal in intact and epithelium-denuded tracheae from saline or endotoxin pretreated guinea-pigs. Similar results are obtained with the combined lipoxygenase/cyclo-oxygenase inhibitor nordihydroguaiaretic acid (10 microM). 4. Histamine (0.1 mM) induces an increase in prostaglandin E2 (PGE2) formation by the tracheal spiral in vitro, which is reduced by 34% by endotoxin pretreatment, and by about 60% following epithelium removal irrespective of endotoxin pretreatment. 5. Arachidonic acid (AA, 22 microM) stimulation of the guinea-...Continue Reading

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Citations

Dec 13, 1991·Pharmaceutisch Weekblad. Scientific Edition·M J LinssenH Timmerman
Oct 15, 1991·European Journal of Pharmacology·H NinomiyaS Hasegawa
Oct 16, 1995·European Journal of Pharmacology·G FolkertsF P Nijkamp
Jan 1, 1990·General Pharmacology·D Raeburn
Mar 23, 2004·European Journal of Pharmacology·U Burcin IsmailogluMustafa Ilhan
Jun 16, 2001·European Journal of Pharmacology·G FolkertsF P Nijkamp
Jun 18, 2002·European Journal of Pharmacology·Joris KloekGert Folkerts
Sep 24, 1998·Trends in Pharmacological Sciences·G Folkerts, F P Nijkamp
Jan 1, 1990·British Journal of Clinical Pharmacology·C P Page
Jan 1, 1993·Fundamental & Clinical Pharmacology·C Bertrand, E Tschirhart
Aug 1, 1995·British Journal of Pharmacology·G FolkertsF P Nijkamp
Jun 1, 1993·The American Review of Respiratory Disease·G FolkertsF P Nijkamp
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·G Folkerts, F P Nijkamp
Jan 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P R GrayM L Peters-Golden
Aug 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·G FolkertsF P Nijkamp
Jan 1, 1990·Experimental Lung Research·C J DoelmanA Bast
Sep 1, 1992·The Journal of Allergy and Clinical Immunology·A J Van OosterhoutF P Nijkamp
Oct 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F P Nijkamp, G Folkerts
Jun 15, 2011·Physiology·Ye Chun RuanHsiao Chang Chan
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joris KloekGert Folkerts
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiangde LiuStephen I Rennard

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