PMID: 9165416Jun 1, 1997Paper

Endotoxin-induced ileal Vo2-Do2 alterations do not correlate with the severity of ileal injury

Journal of Critical Care
E D CrouserP M Dorinsky

Abstract

Altered Vo2-Do2 relationships are most often noted to occur in the setting of sepsis or endotoxin (LPS)-induced systemic organ microvascular injury and are generally thought to be causally linked to that injury. However, we have recently shown that ileal microvascular injury is not associated with altered ileal Vo2-Do2, relationships. Thus, we hypothesized that the severity of LPS-induced systemic organ microvascular injury would not correlate with the development of systemic organ Vo2-Do2 alterations. To test this hypothesis, we used the in situ autoperfused feline ileal preparation to simultaneously examine microvascular permeability, reflected as the ileal lymph to plasma protein concentration ratio (CL/CP), and ileal Vo2-Do2 relationships 2 hours after intravenous LPS (0.75-2.0 mg/kg; n = 9) and in matching controls (n = 5). As expected, all LPS-treated animals were found to have extensive ileal histological damage and marked increases in the CL/CP compared with controls (0.308 +/- 0.019 v 0.097 +/- 0.009; P < .001). In addition, although the critical Do2 (Do2c) was elevated in the LPS-treated animals relative to controls (34.2 +/- 5.0 v 16.7 +/- 1.4 mL/min/kg; P < .03), there was no correlation between the Do2c and the CL/...Continue Reading

References

Aug 1, 1979·Experimental and Molecular Pathology·J J CoalsonL B Hinshaw
Nov 1, 1991·The American Review of Respiratory Disease·R C St JohnP M Dorinsky
Mar 19, 1991·Biochimica Et Biophysica Acta·M T PortolésR Pagani
Dec 1, 1988·The American Review of Respiratory Disease·P M DorinskyJ E Gadek
Jan 1, 1987·Intensive Care Medicine·P T Schumacker, S M Cain
Jan 1, 1981·Journal of Perinatal Medicine·R Terinde
Sep 1, 1995·Journal of Critical Care·D E Taylor, C A Piantadosi
Oct 19, 1995·The New England Journal of Medicine·L GattinoniR Fumagalli
Feb 1, 1995·Acta Anaesthesiologica Scandinavica·G Ostgaard, R K Reed
Jun 16, 1994·The New England Journal of Medicine·M A HayesD Watson
Oct 27, 1994·The New England Journal of Medicine·J L Vincent, D J Bihari
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·E D CrouserP M Dorinsky

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Citations

Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·E D CrouserP M Dorinsky
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·E D CrouserJ A Bauer
Jan 22, 2010·European Journal of Anaesthesiology·Yasser SakrGernot Marx

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