PMID: 2501283May 1, 1989Paper

Endotoxin-induced lung injury in rats: role of eicosanoids

Journal of Applied Physiology
S W ChangN F Voelkel

Abstract

We studied lung vascular injury and quantitated lung eicosanoids in rats after intraperitoneal injection of Salmonella enteritidis endotoxin. Within 40 min after endotoxin injection (20 mg/kg), lung tissue thromboxane B2 doubled, although 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) increased by 8- to 10-fold. Lung 5-hydroxyeicosatetraenoic acid and leukotriene C4 were variably increased by endotoxin. The levels of all eicosanoids returned to base line 6 h after endotoxin challenge. Lung vascular injury, as assessed by the extravascular accumulation of 125I-albumin and water in isolated perfused lungs, was observed 90 min after endotoxin injection (0.02-20 mg/kg) in vivo. Inhibition of the cyclooxygenase pathway with indomethacin and the lipoxygenase pathway with diethylcarbamazine and 2-(12-hydroxydodeca-5,10-dinyl)-3,5,6-trimethyl-1,4-benzoqui none failed to attenuate endotoxin-induced lung injury. In addition, essential fatty acid deficiency, which markedly reduced lung tissue levels of 6-keto-PGF1 alpha, thromboxane B2, and leukotriene C4, did not protect against endotoxin injury. We conclude that although lung eicosanoids are activated during endotoxemia, they do not play a crucial role in the development of acute lung...Continue Reading

Citations

Apr 19, 2003·Transfusion·Christopher C SillimanNorbert F Voelkel
May 1, 1992·Journal of Veterinary Internal Medicine·C W Frevert, A E Warner
Dec 17, 2003·Acta Anaesthesiologica Scandinavica·R S K TakalaR E Aantaa
Mar 1, 1996·Clinics in Chest Medicine·S W Chang, N Ohara
Mar 1, 1996·Clinics in Chest Medicine·R J Panos, S K Baker

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