Endotoxin-induced maturation of MyD88-deficient dendritic cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
T KaishoS Akira

Abstract

LPS, a major component of the cell wall of Gram-negative bacteria, can induce a variety of biological responses including cytokine production from macrophages, B cell proliferation, and endotoxin shock. All of them were completely abolished in MyD88-deficient mice, indicating the essential role of MyD88 in LPS signaling. However, MyD88-deficient cells still show activation of NF-kappaB and mitogen-activated protein kinase cascades, although the biological significance of this activation is not clear. In this study, we have examined the effects of LPS on dendritic cells (DCs) from wild-type and several mutant mice. LPS-induced cytokine production from DCs was dependent on MyD88. However, LPS could induce functional maturation of MyD88-deficient DCs, including up-regulation of costimulatory molecules and enhancement of APC activity. MyD88-deficient DCs could not mature in response to bacterial DNA, the ligand for Toll-like receptor (TLR)9, indicating that MyD88 is differentially required for TLR family signaling. MyD88-dependent and -independent pathways originate at the intracytoplasmic region of TLR4, because both cytokine induction and functional maturation were abolished in DCs from C3H/HeJ mice carrying the point mutation in...Continue Reading

References

Jan 1, 1991·Annual Review of Immunology·R M Steinman
Jan 1, 1995·Annual Review of Immunology·R J Ulevitch, P S Tobias
Oct 1, 1996·The Journal of Experimental Medicine·T De SmedtM Moser
Jan 20, 1997·The Journal of Experimental Medicine·C WinzlerP Ricciardi-Castagnoli
Nov 18, 1997·Cell·R Medzhitov, C A Janeway
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·F L RockJ F Bazan
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jun 20, 1998·The Journal of Biological Chemistry·K BurnsJ Tschopp
Dec 8, 1998·The Journal of Experimental Medicine·M RescignoP Ricciardi-Castagnoli
Feb 17, 1999·The Journal of Experimental Medicine·S T QureshiD Malo
Aug 6, 1999·Immunity·T KawaiS Akira
Aug 17, 1999·Current Opinion in Immunology·C Reis e SousaP Kaye
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L SwantekJ A Thomas
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HirschfeldJ J Weis
Dec 29, 2000·Nature·H HemmiS Akira

❮ Previous
Next ❯

Citations

Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Oct 3, 2002·International Immunology·Katsuaki HoshinoShizuo Akira
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian T Edelson, Emil R Unanue
Oct 25, 2002·AIDS Research and Human Retroviruses·D MessmerM Pope
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Jun 18, 2003·The Journal of Experimental Medicine·Mingfang LuRobert S Munford
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Terry K MeansAndrew D Luster
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franck BihlDanielle Malo
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marianne BoesHidde Ploegh
Nov 26, 2003·Scandinavian Journal of Immunology·R IiyamaM Watanabe
Feb 7, 2004·Cellular Microbiology·Sing Sing WayChristopher B Wilson
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Devin D BolzJanis J Weis
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Slava EpelmanChristopher H Mody
Apr 6, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Subhendu Basu, Matthew J Fenton
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnaud DidierlaurentJean-Claude Sirard
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Theresa E SingletonLee M Wetzler
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·James A PerryAnne C Avery
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy R WeatherillDaniel H Hwang
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michal Cohen-SfadyIrun R Cohen
Mar 1, 2006·Expert Opinion on Biological Therapy·Satoshi Uematsu, Shizuo Akira
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motoko YasutomiMitsufumi Mayumi
Jan 21, 2006·Nature Immunology·Taro Kawai, Shizuo Akira
Jul 7, 2006·Annual Review of Cell and Developmental Biology·A Phillip WestSankar Ghosh
Apr 25, 2006·Experimental Dermatology·Meinhard SchillerMatthias Gunzer
Aug 8, 2006·Nature Immunology·Hidemitsu KitamuraToshio Hirano
Jan 11, 2007·The Journal of Biological Chemistry·Bénédicte LemmersAnne Hakem
Oct 25, 2006·The Journal of Experimental Medicine·Seon-ah HaSidonia Fagarasan
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bei LiuZihai Li
Jan 12, 2007·Periodontology 2000·Nobuyuki UdagawaToshihide Noguchi
Aug 8, 2007·Immunology and Cell Biology·Simon PhippsKlaus I Matthaei
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeremy P McAleerAnthony T Vella
Dec 12, 2007·Bioscience, Biotechnology, and Biochemistry·Shintaro IchikawaYutaka Konishi
Nov 14, 2007·The Journal of Experimental Medicine·Koichiro TakahashiKensuke Miyake
Aug 30, 2008·The Journal of Experimental Medicine·Stefan F MartinMarina A Freudenberg
Jan 6, 2009·Immunological Reviews·Olivier JoffreCaetano Reis e Sousa
Jul 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OnishiShimon Sakaguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds