PMID: 8595520Nov 1, 1995Paper

Endotoxin-induced myocardial dysfunction: is there a role for nitric oxide?

Shock
R S KellerL J Rubin

Abstract

Nitric oxide has been implicated in the regulation of cardiac contractile function as well as the depressed myocardial contractility associated with sepsis and endotoxemia. We examined the effects of nitric oxide synthase (NOS) inhibitors and a nitric oxide generator on contractile responses of left atrial preparations and ventricular myocytes isolated from endotoxemic guinea pigs, which exhibit depressed myocardial contractile function. The NOS inhibitor L-NAME had no effect on contractile tension developed by control atria or atria isolated from guinea pigs 4 or 16 h after an intraperitoneal injection of endotoxin. Similarly, contraction of ventricular myocytes isolated from control or endotoxemic guinea pigs (4 h after endotoxin injection) was unchanged by exposure to several NOS inhibitors. In addition, neither Ca(2+)-dependent nor Ca(2+)-independent ventricular NOS activity was affected by endotoxemia. These data suggest that nitric oxide alone is not responsible for the cardiac contractile dysfunction of endotoxemic guinea pigs.

Citations

Mar 31, 2004·Resuscitation·Milo Engoren, Robert H Habib
Feb 26, 2000·European Journal of Pharmacology·J A MitchellT W Evans
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
Mar 26, 1999·Journal of the American College of Cardiology·M FleschM Böhm
Apr 29, 1998·Journal of Critical Care·S CordaD Payen
Jan 24, 2002·Current Opinion in Critical Care·P B MassionJ L Balligand
Aug 25, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C B CairnsA Banerjee
Oct 16, 2001·Canadian Journal of Physiology and Pharmacology·R MathisonJ S Davison
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·B TavernierV Veksler
Jun 3, 1998·Intensive Care Medicine·R M Grocott-Mason, A M Shah

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