PMID: 3213838Dec 1, 1988Paper

Endotoxin-induced neutrophilic alveolitis and macrophage chemotaxin production in sheep

The American Journal of the Medical Sciences
S S DukeK L Brigham

Abstract

The mechanism(s) responsible for endotoxin-induced pulmonary leukostasis has not yet been elucidated. We studied ten unanesthetized sheep by performing serial bronchoalveolar lavages (BAL) before and after infusing Escherichia coli endotoxin to determine whether or not neutrophils appeared in the airways and whether or not endotoxemia stimulated alveolar macrophages to produce neutrophil chemotactic activity. The absolute number and percentage of neutrophils recoverable by BAL increased significantly at 24 hours after infusion of endotoxin. Alveolar macrophages isolated from the BAL of sheep after endotoxemia produced a substance that is chemotactic for neutrophils, a response that is also maximal 24 hours after endotoxin infusion. We conclude that endotoxemia causes migration of neutrophils into lung air spaces and that this response may result from in vivo production of a chemotactic factor(s) by activated alveolar macrophages.

References

Sep 1, 1985·Agents and Actions·M C Snella, R Rylander
Jun 1, 1984·Circulation Research·K L Brigham, B Meyrick
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·N FreudenbergC Galanos
Feb 1, 1980·The Journal of Clinical Investigation·W W MerrillH Y Reynolds

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Citations

Dec 15, 1991·Klinische Wochenschrift·K L Brigham
Apr 12, 2003·Critical Care Medicine·Theo J MoraesGregory P Downey
Jan 11, 2002·Experimental and Molecular Pathology·Lucille LondonSteven D London
Dec 24, 1997·Environmental Health Perspectives·N ChoeE Kagan

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