Endotoxin inhibits pituitary responsiveness to gonadotropin-releasing hormone

Endocrinology
C Y WilliamsFred J Karsch

Abstract

Immune/inflammatory challenges powerfully suppress reproductive neuroendocrine activity. This inhibition is generally considered to be centrally mediated via mechanisms that regulate GnRH secretion. The present study provides two lines of evidence that bacterial endotoxin, a commonly used model of immune/inflammatory challenge, also acts to inhibit pituitary responsiveness to GNRH: In the first experiment, pulsatile secretion of GnRH into pituitary portal blood and LH into peripheral blood were monitored in ovariectomized ewes treated with a low dose of endotoxin. Although this treatment only marginally suppressed GnRH pulsatile secretion, it markedly disrupted LH pulsatility. In extreme cases, the low dose of endotoxin blocked LH pulses without inhibiting endogenous GnRH pulses, thereby uncoupling GnRH and LH pulsatile suppression. In the second experiment, we tested the hypothesis that endotoxin inhibits pituitary responsiveness to exogenous GnRH pulses. Hourly pulses of GnRH were delivered to ovariectomized ewes in which endogenous GnRH secretion was blocked. Endotoxin suppressed the amplitude of GnRH-induced LH pulses. Together, these observations support the conclusion that endotoxin inhibits pituitary responsiveness to GNRH:

Citations

Dec 6, 2008·Biology of Reproduction·Elizabeth R WagenmakerFred J Karsch
Aug 21, 2013·Clinical & Developmental Immunology·Andrzej Przemysław HermanDorota Tomaszewska-Zaremba
Dec 7, 2013·BMC Veterinary Research·Klaas StrüveHeinrich Bollwein
Sep 10, 2013·Molecular and Cellular Endocrinology·Kellie M Breen, Pamela L Mellon
Mar 30, 2010·Reproduction in Domestic Animals = Zuchthygiene·A P HermanD Tomaszewska-Zaremba
Oct 9, 2004·The Veterinary Clinics of North America. Food Animal Practice·I Martin Sheldon
Apr 1, 2014·Animal : an International Journal of Animal Bioscience·M A CroweE J Williams
Mar 3, 2015·Reproductive Biology·Andrzej Przemysław HermanDorota Tomaszewska-Zaremba
Nov 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karolina WojtulewiczAndrzej Przemysław Herman
Aug 1, 2008·Animal : an International Journal of Animal Bioscience·E J WilliamsI M Sheldon
Jul 1, 2009·Expert Review of Endocrinology & Metabolism·Fred J Karsch, Kellie M Breen
May 19, 2005·American Journal of Physiology. Endocrinology and Metabolism·J A DanielJ L Sartin
Jul 19, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Munkhsaikhan MunkhzayaMinoru Irahara
Feb 9, 2017·Journal of Animal Science·R F CookeJ L M Vasconcelos
Jul 22, 2018·Journal of Animal Science and Biotechnology·Karolina HaziakDorota Tomaszewska-Zaremba
Sep 16, 2019·Molecular and Cellular Endocrinology·Richard B McCoshAlexander S Kauffman

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