Endotoxin levels in periodontally healthy and diseased sites: correlation with levels of gram-negative bacteria

Journal of Periodontology
D H FineJ W Vincent

Abstract

This study investigated the correlation between endotoxin levels and the percentage of Gram-negative bacteria in healthy sites and in periodontitis sites. Twelve healthy adults participated. Each subject provided 3 periodontitis sites with 5 to 8 mm probing depths that bled on gentle probing and 3 healthy sites with sulcus depths of 1 to 3 mm that did not bleed. Clinical examinations and sterile paper point sampling of all study sites were conducted on days 0, 7, and 14, and site-specific endotoxin levels and percentage of Gram-negative bacteria were determined. There were significant differences in both endotoxin levels and percentage Gram-negative bacteria between healthy and periodontitis sites across all 3 sampling periods, but no difference across sampling periods in the healthy sites and the periodontitis sites, respectively. Correlation coefficients revealed a high degree of correlation between site-specific endotoxin levels and percentage of Gram-negative organisms. Using a sample dilution of 1 x 10(4), endotoxin levels differentiated healthy from periodontitis sites with a specificity of approximately 91% and a sensitivity of approximately 90%.

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Citations

Apr 20, 2004·Journal of Periodontology·Yael Houri-HaddadLior Shapira
Apr 20, 2001·International Endodontic Journal·M G KhabbazS N Sykaras
Jun 8, 1999·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·K L KnoernschildG S Schuster
Aug 28, 2007·Journal of Dental Research·C BodetD Grenier
Apr 28, 2012·Journal of Dental Research·R TamaiY Kiyoura
Mar 27, 2003·Periodontology 2000·Marja T PöllänenVeli-Jukka Uitto

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