Endotoxin Nanovesicles: Hydrophilic Gold Nanodots Control Supramolecular Lipopolysaccharide Assembly for Modulating Immunological Responses

Nano Letters
Yueh-Hsia LuoPinpin Lin

Abstract

In this study, we sought to control the assembly of an endotoxin known as the biologically supramolecular lipopolysaccharide (LPS, which consists of three portions: an O antigen, a core carbohydrate, and a lipid A molecule) in order to modulate immunological responses in a manner that has the potential for utilization in vaccine development. Changing the structures of LPS aggregates from lamellas to specific nonlamellas (i.e., cubosomes and hexosomes) can dramatically enhance the strength of LPS in causing inflammatory responses, leading to highly active responses. In order to control the formation of cubosome-free and hexosome-free nonlamellas, we designed a simple strategy based on the use of hydrophilic gold nanodots (AuNDs) to control LPS assembly to facilitate the formation of stable endotoxin nanovesicles, which are stable precursors of cubosomes and hexosomes with specific immunological effects. Structurally, the wall thicknesses of these nanovesicles are exactly twice the lengths of a single LPS molecule, indicating that the LPS molecules adopt a tail-to-tail arrangement (with the lipid A portions acting as the tail domain). The involvement of the hydrophilic AuNDs to laterally link polar domains of LPS can result in th...Continue Reading

References

Aug 1, 1981·Archives of Biochemistry and Biophysics·V GlushkoC D Karp
Dec 1, 1993·European Journal of Biochemistry·K BrandenburgU Seydel
May 12, 2000·European Journal of Biochemistry·U SeydelK Brandenburg
Aug 30, 2000·Nature·A Aderem, R J Ulevitch
Jun 5, 2003·European Journal of Immunology·Ulrich SeydelKlaus Brandenburg
Apr 7, 2005·Journal of the American Chemical Society·Julia J ChiuDavid J Pine
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fernando O MartinezAlberto Mantovani
Apr 25, 2007·International Journal of Medical Microbiology : IJMM·Thomas GutsmannKlaus Brandenburg
Oct 31, 2007·Angewandte Chemie·Brenda L Sanchez-GaytanSo-Jung Park
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Fernando Oneissi MartinezMassimo Locati
Apr 1, 2008·Biophysical Journal·Hirotaka Sasaki, Stephen H White
Aug 19, 2008·Journal of the American Chemical Society·Tao ChenHongyu Chen
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claude SportèsRonald E Gress
Jul 9, 2010·Journal of the American Chemical Society·Yiyong Mai, Adi Eisenberg
Aug 14, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Amanda C KampsSo-Jung Park
Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shankar Subramanian IyerGenhong Cheng
Jan 14, 2011·Chemical Society Reviews·Gad FuksFabienne Gauffre
Mar 1, 2012·The Journal of Physical Chemistry. B·Benjamin W MuirPatrick G Hartley
Jul 11, 2012·Clinical & Developmental Immunology·Ning-Bo HaoShi-Ming Yang
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Brittany D NeedhamM Stephen Trent
Jul 24, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Jiangping XuWei Jiang
Nov 15, 2013·Chemical Communications : Chem Comm·Agrinaldo NascimentoThereza A Soares
Dec 7, 2013·Experimental & Molecular Medicine·Beom Seok Park, Jie-Oh Lee
Jun 19, 2014·Molecular Immunology·Valentina CalabreseFrancesco Peri
Oct 30, 2014·Chemistry : a European Journal·Antonio MolinaroSonsoles Martín-Santamaría
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chih-Te ChienShu-Yi Lin

❮ Previous
Next ❯

Citations

May 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sónia Alexandra Correia Carabineiro
Jun 19, 2019·International Journal of Molecular Sciences·Sibidou YougbareTsung-Rong Kuo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

Deutsche medizinische Wochenschrift
R HAAS, R THOMSSEN
Advances in Experimental Medicine and Biology
A C Allison, N E Byars
MMW Fortschritte der Medizin
Andreas M KaufmannAndreas Prechtl
© 2021 Meta ULC. All rights reserved