PMID: 8967396Apr 1, 1996Paper

Endotoxin shock: thermoregulatory mechanisms

The American Journal of Physiology
A A RomanovskyT Nagasaka

Abstract

To clarify mechanisms of hypothermia in lipopolysaccharide (LPS) shock, four experiments were conducted in 72 chronically instrumented Wistar rats. They were intended to accomplish the following: experiment 1, determine the dose of intravenous Escherichia coli LPS that induces a body temperature (Tb) fall at a minimal mortality [the dose chosen (0.5 mg/kg) was then used in experiments 2-4]; experiment 2, identify the time course of the arterial blood pressure (BP) fall (shock) during the response to LPS; experiment 3, measure threshold Tb values for skin vasodilation and activation of metabolic heat production (M) during the LPS shock; and experiment 4, ascertain behavioral thermoregulation in LPS shock. For experiments 1-3, rats were kept in restrainers; ambient temperature (Ta) was 26 degrees C. In experiment 4, rats freely moved in a thermogradient (18-33 degrees C). Variables monitored were colonic (Tc) and tail skin (Tsk) temperatures (experiment 1); BP (experiment 2); hypothalamic temperature (Thy), M (from oxygen consumption), and Tsk (experiment 3); and preferred Ta (Tpr) and abdominal temperature (experiment 4). In experiment 1, LPS induced no Tc changes at 0 mg/kg, a biphasic fever (no mortality) at 0.05 mg/kg, a biph...Continue Reading

Citations

Aug 6, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alla Y RudayaAndrej A Romanovsky
Jun 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michal Caputa
Nov 10, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph A DiMicco, Dmitry V Zaretsky
Sep 30, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A Romanovsky
Jul 12, 2008·Journal of Applied Physiology·Alexandre A SteinerAndrej A Romanovsky
Apr 30, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisa R LeonMichael D Blaha
Feb 19, 2016·Physiology·Christoph RummelLois M Harden
Mar 18, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Valter DantonioKênia C Bícego
Mar 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna EskilssonAnders Blomqvist
Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K DokladnyP L Moseley
Dec 4, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrei I IvanovAndrej A Romanovsky
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A SteinerAndrej A Romanovsky
Apr 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine M KrallAlexandre A Steiner
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K C Bicego-NahasL G Branco
Jul 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tracey J WeilandStephen Kent
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tomoko HayashiMaripat Corr
Aug 2, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica B BuchananEvelyn Satinoff
Apr 30, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A SteinerAndrej A Romanovsky
Nov 26, 2009·Avian Pathology : Journal of the W.V.P.A·S De BoeverP De Backer
Nov 3, 2009·The Journal of Physiology·R M McAllen
Sep 21, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Kathleen M KokolusElizabeth A Repasky
Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A Romanovsky
Apr 20, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elaine LiuAlexandre A Steiner
Aug 5, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth A FlatowAlexandre A Steiner
Mar 16, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey E GottsMichael A Matthay
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eyup S Akarsu, Soner Mamuk
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T MizunoT Sugano
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·A M CoelhoL Buéno
Jun 22, 2014·The Journal of Physiology·Joshua J CorriganAlexandre A Steiner
Apr 22, 2021·Science Signaling·Monique T FonsecaAlexandre A Steiner
Apr 7, 2021·The Journal of Physiology·Lara do Amaral-SilvaKênia Cardoso Bícego

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.