Endotoxin-stimulated opioid peptide secretion: two secretory pools and feedback control in vivo

D B CarrM Rosenblatt


Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of beta-endorphin to beta-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in beta-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.


Jun 1, 1994·Pflügers Archiv : European journal of physiology·M HashimotoY Shimada
Jul 1, 1985·Pflügers Archiv : European journal of physiology·R F HellonW I Cranston
May 1, 1984·Canadian Anaesthetists' Society Journal·B Milne, K Jhamandas
Mar 11, 1985·Brain Research·S Amir, J M van Ree
May 30, 1983·Life Sciences·S M Fishman, D B Carr
Feb 16, 1987·Life Sciences·S E WeinbergerM Rosenblatt
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·O F Pomerleau, C S Pomerleau
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·C J GordonJ E Heath
Sep 1, 1989·Immunopharmacology·R PerriconeL Fontana
Jun 1, 1987·Immunology Letters·B D Janković, D Marić
Jan 1, 1985·Peptides·W KraemerR V Lewis
Nov 1, 1985·Peptides·M S AhmedC M Blatteis
Dec 1, 1985·Brain Research Bulletin·R A AhokasC M Blatteis
Feb 1, 1991·Brain Research Bulletin·C M BlatteisN Quan
Jun 1, 1987·Brain, Behavior, and Immunity·D V HarbourJ E Blalock
Dec 1, 1988·Brain, Behavior, and Immunity·D J Carr, J E Blalock
Aug 5, 2000·European Journal of Pharmacology·K BenamarM W Adler
May 20, 1998·Pharmacology, Biochemistry, and Behavior·Y ShavitR Yirmiya
Oct 24, 1998·Domestic Animal Endocrinology·P S KalraS P Kalra
Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·M FatehiZ Fatehi-Hassanabad
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W J KraemerR V Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.