PMID: 9655478Jul 9, 1998Paper

Endotoxin stimulates an endogenous pathway regulating corticotropin-releasing hormone and vasopressin release involving the generation of nitric oxide and carbon monoxide

Journal of Neuroimmunology
I Kostoglou-AthanassiouA B Grossman

Abstract

Although the administration of endotoxin in vivo activates the neuroendocrine stress axis in the process of crosstalk between the immune and endocrine axes, the direct application of endotoxin to the hypothalamus in vitro does not stimulate the release of the hypothalamic peptides controlling the hypothalamo-pituitary-adrenal (HPA) axis, corticotropin-releasing hormone (CRH) and vasopressin. The hypothesis has therefore been tested that endotoxin may also activate inhibitory pathways, specifically those involving the generation of nitric oxide (NO) and carbon monoxide (CO). Studies were performed on the isolated rat hypothalamus using endotoxin in the presence or absence of inhibitors of heme oxygenase (which generates CO) and nitric oxide synthase, and ferrous hemoglobin. Endotoxin alone decreased both CRH and vasopressin secretion from the hypothalamus. However, when applied together with a nitric oxide synthase inhibitor, the inhibitory effect on CRH was lost. Conversely, co-administration with heme oxygenase inhibitors transformed the inhibition of vasopressin to stimulation, while having no effect on the inhibition of CRH. Ferrous hemoglobin reversed the inhibition of vasopressin, but did not lead to stimulation. It is the...Continue Reading

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Citations

May 18, 2005·Neuroscience Letters·Alexandre Giusti-PaivaJosé Antunes-Rodrigues
Jul 7, 1999·Neuroscience and Biobehavioral Reviews·E Gahtan, J B Overmier
Apr 20, 2001·British Journal of Pharmacology·A A SteinerS H Ferreira
May 15, 2002·Antioxidants & Redox Signaling·Cynthia L Hartsfield
Feb 25, 2009·Annals of the New York Academy of Sciences·Istvan BercziKalman Kovacs
Jul 25, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·A Mulla, J C Buckingham
Aug 13, 2013·Journal of Affective Disorders·Mark A McEvoyJohn Attia
Mar 1, 2001·Stress : the International Journal on the Biology of Stress·P NavarraA Grossman
Mar 28, 2001·Annals of the New York Academy of Sciences·P NavarraA Grossman
Mar 3, 2015·Physiology·Silvia Graciela RuginskJose Antunes-Rodrigues
Nov 21, 2000·Rheumatic Diseases Clinics of North America·I C Chikanza, A B Grossman

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