PMID: 8611169Feb 1, 1996Paper

Endotoxin suppresses rat hepatic low-density lipoprotein receptor expression

The Biochemical Journal
W LiaoB Angelin

Abstract

Endotoxin induces hyperlipidaemia in experimental animals. In the current study, we investigated whether endotoxin alters hepatic low-density lipoprotein (LDL) receptor expression in rats. Endotoxin treatment suppressed hepatic LDL receptor expression in a dose- and time-dependent manner. Eighteen hours after intraperitoneal injection of increasing amounts of endotoxin, LDL receptor and its mRNA levels were determined by ligand blot and solution hybridization respectively. LDL receptor expression was inhibited by about 70% at a dose of 500 micrograms/100 g body weight. However, LDL receptor mRNA levels were markedly increased in all endotoxin-treated groups at this time point (by 83-136%; P < 0.001). Time-course experiments showed that LDL receptor expression was already reduced by 48% 4 h after endotoxin injection and was maximally reduced (by 63-65%) between 8 and 18 h. Changes in hepatic LDL receptor mRNA showed a different pattern. By 4 h after endotoxin injection, LDL receptor mRNA had decreased by 78% (P < 0.001). However, by 8 h after endotoxin injection, LDL receptor mRNA had returned to levels similar to controls, and 18 and 24 h after endotoxin injection, they were increased by about 60% (P < 0.05). Separation of plas...Continue Reading

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Citations

Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kara N MaxwellJan L Breslow
Dec 25, 2003·The Proceedings of the Nutrition Society·Simon Eaton
Oct 30, 2019·Journal of Internal Medicine·C SchoergenhoferB Jilma
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W LiaoB Angelin
Oct 23, 2012·Pharmacological Reports : PR·Hong-Bo XiaoDa-Sheng Zhang
Jan 12, 2002·Nature Medicine·Ville WalleniusJohn-Olov Jansson
Aug 9, 2016·Current Opinion in Lipidology·Kenneth R Feingold, Carl Grunfeld
Nov 1, 1996·The Journal of Laboratory and Clinical Medicine·W Liao
Jul 22, 2008·Biochemical and Biophysical Research Communications·Kenneth R FeingoldCarl Grunfeld

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