Endotoxin temporarily impairs canine colonic absorption of water and sodium

The Journal of Surgical Research
J J CullenM M Hinkhouse

Abstract

Diarrhea is a common manifestation of sepsis. We hypothesized that endotoxin may impair colonic absorption of water and electrolytes, an effect which may be related to altered liquid transit in the colon. Five dogs underwent construction of 50-cm colonic Thiry-Vella fistulas (TVF). Following recovery, absorption studies were performed by perfusing the TVF with an isotonic solution at 2.9 ml/min containing polyethylene glycol (5 g/L). Fasting and postprandial colonic absorption of water, electrolytes, and glucose were determined. Liquid transit was assessed by bolus of a nonabsorbable marker (PSP) instilled into the proximal end of the TVF. Following completion of the baseline studies, each dog was given a single dose of Escherichia coli lipopolysaccharide 200 micrograms/kg i.v. and the studies were repeated daily for the next 3 days. Following endotoxin bolus, colonic absorption of water and sodium were decreased during fasting, while postprandial colonic absorption of water was also decreased. Colonic absorption of water and sodium returned to baseline values on postendotoxin day 2. Colonic secretion of potassium was decreased on postendotoxin days 1 and 3 in both the fasting and the fed periods. Fasting and postprandial liqui...Continue Reading

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Citations

May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·M A HigginsT P Ryan
Feb 4, 2006·American Journal of Veterinary Research·David C HernotPatrick G Nguyen
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M J BruinsN E P Deutz
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Apr 11, 2009·Autonomic Neuroscience : Basic & Clinical·G GakisM E Kreis
Jun 10, 2004·World Journal of Gastroenterology : WJG·Jian-Min SiShu-Jie Chen

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