Endotoxin tolerance does not alter open field-induced fever in rats

Physiology & Behavior
D SoszynskiM J Kluger

Abstract

Exposure to an open field has been shown to cause a rise in the body temperature of rats. In many respects, this rise in body temperature is similar to fevers caused by endotoxin and other inflammatory stimuli. Rats repeatedly injected with endotoxin develop tolerance to the fever-inducing action of endotoxin. We hypothesized that repeated pretreatment with endotoxin would modify the fever caused by exposure to psychological stress. To test this hypothesis, we compared open field-induced fevers in rats made endotoxin tolerant to those rats not endotoxin tolerant. We found that endotoxin tolerance had no effect on open field fevers.

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Citations

Dec 9, 2000·Physiology & Behavior·D De PaulaL G Branco
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Takakazu Oka
Apr 19, 2008·European Journal of Pharmacology·Christiaan H VinkersLucianne Groenink
Jan 25, 2020·The Journal of Experimental Biology·Joshua K RobertsonGary Burness

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