PMID: 8587803Jan 1, 1996Paper

Endotoxins in the blood and cerebrospinal fluid of patients with African sleeping sickness

Parasitology
V W PentreathB A Oppenheim

Abstract

Endotoxin levels were measured in the blood and cerebrospinal fluid (CSF) of control individuals and 2 groups of patients with African sleeping sickness. Endotoxin levels were markedly elevated in the blood (infected groups mean endotoxin values 40.2 pg/ml and 53.8 pg/ml, compared to control 11.6 pg/ml, P < 0.0001 for both increases) and CSF (infected groups mean endotoxin values 45.8 pg/ml and 50.1 pg/ml compared to control 6.3 pg/ml, P < 0.0001 for both increases) of the patients. The levels were reduced 6 weeks following different drug treatments in the 2 groups (blood levels to mean 33.8 pg/ml and 28.5 pg/ml; CSF levels to 37.4 pg/ml and 27.0 pg/ml). The blood endotoxin values correlated with the CSF values before treatment (r = 0.74 and 0.57 for the 2 groups; P < 0.0001 for both) and after treatment (r = 0.57 and 0.56 for the 2 groups; P < 0.0001 for both). It is concluded that raised endotoxin equilibrates in the blood and CSF compartments, and may contribute significantly to the pathology of sleeping sickness.

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Citations

Mar 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·J N Nyakundi, V W Pentreath
Nov 9, 2000·The Journal of Experimental Medicine·B K KubataO Hayaishi
Jun 9, 2012·Parasites & Vectors·João Carlos Araujo CarreiraReginaldo Peçanha Brazil
May 24, 2012·TheScientificWorldJournal·Samantha Salomão CaramoriLuiz Bezerra de Carvalho Junior
Feb 3, 2004·Annals of Tropical Medicine and Parasitology·M Ben-RashedV W Pentreath
Jul 17, 2014·Bioscience Reports·Jonghoon ChoiKwan Hyi Lee
May 1, 1997·Clinical Immunology and Immunopathology·S G RhindM W Radomski
Mar 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toolika SinghJenefer M Blackwell
Mar 20, 2001·Genetic Epidemiology·C S PeacockJ M Blackwell
Mar 8, 2008·Nature Reviews. Immunology·Robert A SederMario Roederer
Nov 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anne F McGettrickDerek P Nolan
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anuratha SakthianandeswarenSimon J Foote
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J MatthewsA N McKenzie
Aug 17, 2004·Scandinavian Journal of Infectious Diseases·Selma M B JeronimoMary E Wilson
Oct 13, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ciana DiskinLuke A J O'Neill

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