Endotoxins isolated from the air of a Danish paper mill and the relation to change in lung function: an 11-year follow-up

American Journal of Industrial Medicine
T SigsgaardGert Thomsen

Abstract

A decline in lung function has been associated with farming, cotton spinning, and work in the animal feed industry. The aim of the study was to reveal if loss of lung function was associated to work at a paper mill. Ninety-seven male paper workers (PW), and 55 control workers were examined. Hygiene samples included total dust, endotoxins, and microorganisms. Interview, pulmonary function testing, and skin prick test (SPT) were performed and yearly decline in lung function was calculated. The exposure for endotoxin (LPS) ranged from Median (Max-Min) 69 (370-6) EU/m3, in the wet-end of the paper machines to 6 (19-16) in the pulping area. The lung function decline among the controls was comparable to the decrements among the maintenance and repair workers at the paper factory, around 51-54 and 37-38 ml/year among smokers' and non-smokers, respectively. After adjustment for baseline FEV1, the variables associated to an increased loss of FEV1 were age smoking and cough. For FVC we found an inverse relation between exposure and yearly decline. No increase in loss of lung function is seen among workers exposed to up to 200 EU/m3 of LPS.

References

Feb 11, 1991·The American Review of Respiratory Disease·E ZuskinT J Witek
Jan 1, 1986·European Journal of Nuclear Medicine·P VernonW A Seed
Nov 1, 1986·The Journal of Applied Bacteriology·U PalmgrenP Malmberg
Oct 1, 1983·Applied and Environmental Microbiology·S A OlenchockP L Lu
Jul 1, 1984·Annals of Internal Medicine·G J BeckR S Schilling
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·D C ChristianiP L Lu
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·H W GlindmeyerH Weill
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·P F VogelzangC P van Schayck
Mar 23, 1999·American Journal of Industrial Medicine·D C ChristianiH L Dai
Jan 29, 2002·American Journal of Industrial Medicine·Xiao-Rong WangDavid C Christiani
Jan 30, 2003·Occupational and Environmental Medicine·X-R WangD C Christiani

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Citations

Mar 7, 2008·Archives of Toxicology·V LiebersT Brüning
Apr 14, 2017·Occupational and Environmental Medicine·Anneli Cs BolundVivi Schlünssen
Feb 10, 2018·Environmental Health : a Global Access Science Source·Azadèh FarokhiLidwien A M Smit
Nov 15, 2007·Journal of Occupational and Environmental Medicine·Liv I B SikkelandJohny Kongerud
Apr 6, 2006·American Journal of Industrial Medicine·Verena LiebersMonika Raulf-Heimsoth
May 12, 2012·Journal of Occupational and Environmental Medicine·Stephen J ReynoldsJames B Burch
May 23, 2018·Environmental Science & Technology·Yang YueMaosheng Yao

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