PMID: 8960511Nov 1, 1996Paper

Endovascular beta-irradiation after percutaneous transluminal coronary balloon angioplasty

International Journal of Radiation Oncology, Biology, Physics
Y PopowskiP Urban

Abstract

Intraluminal beta-irradiation has been shown to markedly decrease fibrointimal proliferation after arterial injury in experimental models. With the aim of reducing the incidence of restenosis after percutaneous transluminal coronary angioplasty (PTCA), we undertook a pilot clinical evaluation to assess both the technical feasibility and the clinical safety of this treatment after balloon coronary angioplasty. Between June 21 and November 15, 1995, 15 patients (6 women and 9 men, aged 72 +/- 5 years) underwent intracoronary beta-irradiation immediately after a conventional PTCA procedure. Both the PTCA and irradiation procedure were done in a conventional catheterization laboratory, using an endoluminally centered pure metallic 90Y source, a newly developed technique of intracoronary beta-irradiation. This was done after documenting the ability of the system to generate reproducible dose delivery to the arterial wall. Both the PTCA and the irradiation procedure were technically feasible in all attempted cases, and a dose of 18 Gy was delivered with a local exposure time of 391 +/- 206 s (range 153-768). In four patients, the intervention was completed by intraarterial stent implantation because of dissection induced by the initi...Continue Reading

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Nov 1, 1996·International Journal of Radiation Oncology, Biology, Physics·Y PopowskiJ M Kurtz

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Citations

Sep 19, 2001·Australasian Physical & Engineering Sciences in Medicine·N BoeingM A Ebert
Nov 17, 1998·Surgical Neurology·G P TeitelbaumS L Giannotta
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·J C MenendezJ R Berrazueta
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·B E PowersE L Gillette
Jul 10, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Mythili A MajaliSangeeta H Joshi
Jun 9, 1998·Journal of Vascular and Interventional Radiology : JVIR·D A Diamond, T M Vesely
Mar 7, 2000·Journal of the American College of Surgeons·K A IlligR M Green
Mar 4, 2000·The British Journal of Radiology·B Jones
Jan 19, 1999·Vascular Medicine·A H Gershlick

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